Ultrasound can be used to have a variety of effects in a
living organism including directing the flow of fluids. Researchers at The
University of Texas at Arlington PLGA (AP040) from PolySciTech Division of
Akina, Inc. (www.polyscitech.com)
used in development of fluorescently tagged nanoparticles to track fluid
behavior under ultrasound. This research holds promise to improve understanding
of ultrasound fluid-flow effects in living organisms. Read more: Ren,
Liqin, Na Thi Vy Nguyen, Tingfeng Yao, Kytai T. Nguyen, and Baohong Yuan.
"Experimental studies on squeezing interstitial fluid via transfer of
ultrasound momentum (SIF-TUM) in ex vivo chicken and porcine
tissues." Journal of Applied Physics 137, no. 13 (2025). https://pubs.aip.org/aip/jap/article/137/13/135103/3340188
“The ultrasound-assisted transport of drugs or
fluorophore-loaded nanoagents plays an important role in the desirable drug
delivery and imaging contrasts. Unlike conventional ultrasound techniques that
rely on thermal or cavitation effects, this study aims to conduct an
experimental investigation into the dynamics of interstitial fluid streaming
and tissue recovery in ex vivo chicken breast and porcine loin muscle tissues
during and after ultrasound exposures, which has not been experimentally
investigated in the literature. Biological tissues consist of both a fluid and
a solid matrix, and an ultrasound beam compresses the tissues within a small
focal volume from all directions, which generates macroscopic streaming of
interstitial fluid and compression of the tissue's solid matrix. After the
ultrasonic exposure, the solid matrix undergoes recovery, leading to a backflow
of the fluid matrix. Temperature-insensitive sulforhodamine-101 encapsulated
poly(lactic-co-glycolic acid) nanoparticles with an average diameter size of
175 nm were locally
injected into ex vivo chicken breast and porcine loin muscle tissues to study
the ultrasound-induced dynamics in the tissues during and after ultrasound
exposure by analyzing the distribution of fluorescence. The changes in
fluorescence over time caused by the streaming and backflow of interstitial
fluid were studied with two ex vivo tissue models, and a faster recovery was
observed in porcine tissues compared with chicken tissues. The
ultrasound-induced transportability of the nanoagent in porcine muscle tissues
was much higher (∼8.75 times) than in chicken breast tissue likely due to
structural differences. The study reveals a promising, non-invasive strategy
for enhancing drug delivery in dense tissues by leveraging mechanical
ultrasound effects, potentially advancing therapeutic and diagnostic
applications.”
PLGA (Cat# AP040): https://akinainc.com/polyscitech/products/polyvivo/index.php?highlight=AP040#h
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Video: https://youtu.be/EPCZiTiIwhw
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