PLGA from PolySciTech used in development of timed release patch for treatment of heart disease

 

Myocardial infarction (MI) remains one of the most pressing global health problems, leaving millions of patients with long-term cardiac dysfunction despite advances in acute surgical care. Researchers at Massachusetts Institute of Technology used multiple PLGAs from PolySciTech Division of Akina, Inc. (www.polyscitech.com) to develop a drug delivery system to release drugs into the heart tissue in a timed sequence. This research holds promise to improve treatment of heart disease. Read more: Erika Yan Wang, Elizabeth A. Calle, Binbin Ying, Behnaz Eshaghi, Linzixuan Zhang, Xin Yang, Stacey Qiaohui Lin, Jooli Han, Alanna G. Backx, Yuting Huang, Sevinj Mursalova, Chuhan Joyce Qi, Yi Liu, Robert Langer, Ana Jaklenec "TIMED: Temporal intervention with microparticle encapsulation and delivery—A programmed release system for post-myocardial infarction therapy." Cell Biomaterials (2025). https://www.cell.com/cell-biomaterials/abstract/S3050-5623(25)00240-5

“Myocardial infarction (MI) is a major global health challenge. Surgical interventions address the acute phase but often fail to support long-term recovery. Sequential post-operative drug delivery offers promise but is constrained by release methods. Here, we developed TIMED (temporal intervention with microparticle encapsulation and delivery), a polymeric device enabling programmed sequential release through spatially patterned microparticles in a tough hydrogel matrix. TIMED demonstrated excellent mechanical performance and biocompatibility for long-term implantation and retained strong stability after storage. A sequential dosing regimen aligned with the innate post-MI response was first validated in hiPSC-derived cardiac tissues, where it enhanced cell viability and vascularization while reducing collagen deposition. In vivo, delivery via the TIMED improved survival, reduced injury markers and infarct size, and enhanced cardiac output, outperforming equivalent i.v. dosing. This work establishes a first-of-its-kind cardiac implantable polymeric platform with modular sequential release and provides a framework for programmed multi-dosing across diverse applications.”

Multiple PLGA (https://akinainc.com/polyscitech/products/polyvivo/polyesters.php)

Benchtop to Bedside with MidWest GMP https://www.akinainc.com/midwestgmp/

Corbion Purasorb® Polymers: https://akinainc.com/polyscitech/products/purasorb/

Ashland-TM Polymer Products: https://akinainc.com/polyscitech/products/ashland/

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