PLGA from PolySciTech used in development of bone-tissue scaffolding for tissue regeneration

 

In order to heal defects in bone caused by either disease or trauma, there needs to be a scaffold or a structure for bone cells to attach to and grow. Ideally this structure would mimic the properties of the natural extracellular matrix of bone. Researchers at Pennsylvania State University and Westlake University (China) Used PLGA (Cat# AP230, https://akinainc.com/polyscitech/products/polyvivo/index.php?highlight=AP230#h) from PolySciTech : Akina, Inc. (www.PolySciTech.com) as part of their development of bone tissue scaffolding. This research holds promise to improve regenerative medicine. Read more: Wang, Yuqi, Su Yan, Xinyu Tan, Ethan Gerhard, Hui Xu, Haiyue Jiang, and Jian Yang. "The genesis of citrated ultrathin hydroxyapatite nanorods." Science Advances 12, no. 3 (2026): eaeb6538. https://www.science.org/doi/full/10.1126/sciadv.aeb6538

“Ideal orthopedic biomaterials should replicate both the hierarchical structure and exceptional mechanical strength of natural bone. Traditional polymer-hydroxyapatite composites, typically limited up to 40 wt % hydroxyapatite, offer only modest mechanical improvements. Efforts to enhance strength by using stiffer polymers have largely failed, as increased polymer stiffness does not translate to improved composite mechanics. In contrast, natural bone’s load-bearing capability arises from the synergy between citrate, soft collagen, and ultrathin hydroxyapatite nanocrystals (~3 nanometers). Here, we show that elastic poly(octamethylene citrate) enables up to 60 wt % hydroxyapatite incorporation, mimicking the bone’s mineral content. Through a top-down “citrification” process and hot pressing, hydroxyapatite microparticles are partially dissolved and recrystallized into superthin (~5 nanometers) nanorods, enhancing organic-inorganic integration and replicating bone’s Ca/P ratios and architecture. The resulting composites exhibit compressive strengths exceeding 250 megapascals, unprecedented in polymer-mineral systems, offering a molecular design strategy for next-generation load-bearing orthopedic implants.”

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