PolySciTech (
www.polyscitech.com) provides a wide
array of PLGA copolymers. Recently these types of polymers were utilized along
with stem-cells and BMP-2 to create a tissue scaffold for repair of bone. Read
more: Rodriguez-Evora, Maria, Emiliano Garcia-Pizarro, Carlos Del Rosario,
Javier Perez-Lopez, Ricardo Reyes, Araceli Delgado, Jose C. Rodriguez-Rey, and
Carmen Evora. "Smurf1 knocked-down, mesenchymal stem cells and BMP-2 in an
electrospun system for bone regeneration." Biomacromolecules 15, no. 4
(2014): 1311-1322.http://pubs.acs.org/doi/abs/10.1021/bm401854d
“Abstract: A sandwich-like system, fabricated
with electrospun, poly(lactic-co-glycolic-acid) (PLGA) membranes incorporating
either human recombinant bone morphogenetic protein 2 (BMP-2) enriched
microspheres, rat bone marrow mesenchymal stem cells (rMSC), or rMSC with their
Smurf1 (SMAD ubiquitin regulatory factor-1) expression knocked down by means of
siRNA (rMSC573) at varying densities was evaluated in a rat calvarial,
critical-size defect. The behavior of four membrane varieties, fabricated with
different PLGA copolymers, was initially studied in rMSC cultures to decide on
optimal membrane degradation and cell proliferation and differentiation
characteristics. PLGA75:25 provided the most stable structure, and favored the
cell environment. Radiological and histological analyses indicated bone repair
in animals treated with the PLGA75:25 bioactivated systems. We found no
synergist interaction between BMP-2 and rMSC 8 to 12 weeks postimplantation. By
contrast, synergistic defect repair of around 85% was detected after 8 weeks of
combined BMP-2 and rMSC573 treatment.”
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