PolySciTech (www.polyscitech.com) provides a wide
array of biodegradable polyesters. This includes 3-arm P(DL)La-glycerol
(Mw~15kDa) product number AP092. Recently this material was used for
formulating nanoparticles for curcumin delivery which displayed prolonged
circulation of curcumin in rat model and good in-vitro anti-cancer activity.
Read more: Yoon, In-Soo, Ju-Hwan Park, Hyo Jin Kang, Ji Hyeong Choe, Min Su
Goh, Dae-Duk Kim, and Hyun-Jong Cho. "Poly (d, l-lactic
acid)-glycerol-based nanoparticles for curcumin delivery." International
Journal of Pharmaceutics (2015). http://www.sciencedirect.com/science/article/pii/S0378517315003543
“Abstract: Poly(d,l-lactic
acid)-glycerol (PDLLA-G)-based nanoparticles (NPs) were fabricated for the
intravenous delivery of curcumin (CUR). NPs with a mean diameter of
approximately 200 nm, a narrow size distribution, and capable of efficient drug
encapsulation were prepared using an emulsification-solvent evaporation method.
The stability of NPs was verified in water, phosphate buffered saline (PBS),
and serum after 24-h incubation. A sustained drug release pattern was observed,
and the amount of CUR released in acidic media (pH 5.5) was higher than in
media at physiological pH (pH 7.4). Blank NPs (without drug loading) did not
exhibit severe cytotoxicity in MDA-MB-231 human breast adenocarcinoma cells.
The in vitro anti-tumor efficacy of CUR-loaded NPs in MDA-MB-231 cells was
comparable to that of a solution of CUR. Pharmacokinetic studies in rats showed
that the in vivo clearance (CL) of CUR in the NP-treated group was lower than
the group treated with CUR solution. Therefore, encapsulation of CUR in PDLLA-G
NPs was shown to enable prolonged circulation of the drug in the blood stream
and guarantee improved anticancer activity after intravenous injection. These
biocompatible NPs could be an efficient nano-sized injectable formulation for
CUR delivery.”
No comments:
Post a Comment