PolySciTech (www.polyscitech.com) provides a wide
array of biodegradable block copolymers
including mPEG-PLGA. Recently these types of polymers were used as a precursor
for a 2,2-bis(2-oxazoline) crosslinked nanogel designed for ocular delivery of
bevacizumab. Read more: Hu, Chao-Chien, Jen-Ray Chaw, Yu-Chih Chen, Chin-Fu
Chen, and Hsia-Wei Liu. "A Novel Thermo-Responsive Nanogel for Intraocular
Drug Delivery." Journal of Computational and Theoretical Nanoscience 12,
no. 5 (2015): 762-768. http://www.ingentaconnect.com/content/asp/jctn/2015/00000012/00000005/art00012
“Abstract: The novel
amphiphilic hydrophilic–hydrophobic block copolymers of methoxy-poly(ethylene
glycol)-block-poly(lactic-co-glycolic acid) (mPEG-PLGA) were synthesized by the
ring-opening polymerization, cross-linked with 2,2-bis(2-oxazoline) (BOX) and
the chemical structures were characterized by 1H nuclear magnetic resonance
(1H-NMR). Cross-linked mPEG-PLGA-BOX block copolymers formed a core–shell
micellar structure with a critical micelle concentration of 9.21 × 10–4 mg/mL.
The mPEG-PLGA-BOX micelles were spherical with a hydrodynamic diameter of
between 26.10 nm to 39.70 nm. A solution containing mPEG-PLGA-BOX micelles
exhibited a fast and reversible sol–gel phase transition behavior that could
convert into nanogels at body temperature. The pharmacokinetic release rate of
anti-vascular endothelial growth factor (VEGF) entrapped in nanogels were
examined in vitro. Release profiles of the anti-VEGF agents (bevacizumab)
showed that there was sustained release for approximately 30 days. Released
bevacizumab inhibited the RF6A cells growth, which showed drug delivery system
may provide localized and sustained release of bevacizumab over an extended
period. The mPEG-PLGA-BOX nanogel has been successfully synthesized and
determined as thermosensitive and biocompatible. This suggests that the nanogel
may be considered as a novel biomaterial with potential as the form of
injectable dilute dispersions or as in situ gelling carrier for extended
anti-VEGF drug release to treat intraocular neovascular diseases.”
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