PolySciTech PLGA used for development of episcleral drug delivery
PolySciTech (www.polyscitech.com)
provides a wide array of biodegradable polymers. Recently, a PLGA 85:15 (cat#
AP087) was utilized by University of Cincinnati as part of their research for development
of an adhesive ocular drug release system. Read more: Wen, He, and S. Kevin Li.
"Characterization of silicone pressure-sensitive adhesive episcleral
implant for drug delivery." Drug Development and Industrial Pharmacy 0
(2015): 1-9. http://informahealthcare.com/doi/abs/10.3109/03639045.2015.1035280
“Abstract: The development of an effective sustained
ocular drug delivery system remains a challenging task. The objective of the
present study was to characterize a silicone pressure sensitive adhesive (PSA)
episcleral implant system for transscleral drug delivery. Silicone PSA implants
for dexamethasone, atenolol, and bovine serum albumin (BSA) were prepared at
different polymer-to-drug mass ratios. Implant adhesion to human cadaver sclera
was measured. Drug release experiments were conducted in well-stirred containers
in vitro. The results were then analyzed using a pharmacokinetic model and in
vitro–in vivo data comparison from previous studies. The silicone PSA
episcleral implants in the present study had an average diameter of 3.5 mm and
a thickness of 0.8 mm. Drug release from the silicone PSA implants was
influenced by drug solubility, implant polymer content, and implant coating.
Drug release from the implants was observed to follow the receding boundary
release mechanism and was solubility dependent with the higher water solubility
drug showing higher release rate than the low-solubility drug. Increasing
polymer content in the implants led to a significant decrease in the drug
release rate. Coated implants reduced the initial burst effect and provided
lower release rates than the uncoated implants. These implants provided
sustained drug release that could last up to several months in vitro and
demonstrated the potential to offer drug delivery for chronic ocular diseases
via the transscleral route. Keywords: Controlled release, episcleral implant,
macromolecules, silicone adhesive, transscleral delivery”
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