Glaucoma,
a disease in which damage to the optic nerve leads to eventual blindness, involves
oxidative stress that leads to extensive optic
nerve injury. Preventing oxidative stress (e.g. reducing reactive oxygen
species formation with the cells) is an effective means to prevent cellular
death and delay nerve damage. It has been found that reducing agents (such as phenylphosphine-borane
complexes) can act to prevent the over-formation of reactive oxygen species and
reduce nerve damage from Glaucoma. Administering these medicines over the
course of this chronic disease, however, requires repeat injections in the same
ocular location, which is inconvenient to both patient and provider. A better
strategy is to deliver a single injection every few months which delivers the
neuroprotective agent in a controlled manner. Recently, researchers
working at University of Wisconsin and McGill University (Canada) utilized many
degradable polyesters (PLGA, PLA, PLCL, PDOCL) from PolySciTech (www.polyscitech.com) (PolyVivo cat#
AP001, AP002, AP003, AP004, AP006, AP007, AP008, AP010, AP011, AP013, AP014,
AP016, AP017, AP018, AP020, AP021, AP023, AP024, AP030, AP031, AP032, and AP034)
to develop such a controlled delivery system. This research holds promise for
improved glaucoma therapy to delay the progression of this disease. Read more: Janus, David A., Christopher J. Lieven,
Megan E. Crowe, and Leonard A. Levin. "Polyester-Based Microdisc Systems
for Sustained Release of Neuroprotective Phosphine-Borane
Complexes." Pharmaceutical Development and Technology just-accepted
(2017): 1-32. http://www.tandfonline.com/doi/abs/10.1080/10837450.2017.1333516
Blog dedicated to answering technical questions in an open format relating to PolySciTech (A division of Akina, Inc.) products.
Friday, May 26, 2017
PolySciTech polyesters used in development of neuroprotective controlled-delivery system for glaucoma treatment
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