All materials generated by the PolySciTech division of Akina, Inc. (www.polyscitech.com) undergo a rigorous
set of chemical characterization tests. These typically include
Fourier-transform infrared spectrophotometry (FTIR) scan, proton nuclear
magnetic resonance (HNMR), and gel-permeation chromatography (GPC). The FTIR
test gives information on specific chemical moieties included in the material
based on their particular absorption peaks/bands. The HNMR test provides
further chemical characterization by providing peaks which correspond to
specific shifts based on hydrogen local environment. This also allows for proton-counting
to be used for determining polymer features. For example the lactide-to-glycolide
ratio in PLGA can be determined by comparing the peak integration at 5.2 ppm
(1H, lactide) with the integration at 4.8 (2H, glycolide). Gel-permeation
chromatography yields data on the molecular weight of the polymer as well as
the distribution of polymer chain lengths. The data from these tests are shown
directly on the certificate of analysis (COA) to provide the customer with a
thorough set of chemical characterization data. Recently, Akina, Inc. has compiled the COAs
for both currently available batches as well as historical batches of material
into an online, searchable format. This allows for pulling up data both on historical
batches purchased some time ago as well as reviewing COAs for current
materials. Note that, as long as enough material is in stock to fill the order,
you can request a specific batch on an order at no additional charge by
indicating the batch on the order or in the ‘Special notes’ section on the
online order form. See the searchable set of COAs here (https://akinainc.com/polyscitech/products/polyvivo/COA.php)
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