Pancreatic cancer is a form of cancer which is very
difficult to treat and can often be fatal. Peptides, such as polylysine, have
been found to slow the growth of cancer however delivering them to the cancer
site is difficult. Recently, researchers working at Universidad Nacional de Mar
del Plata, Universidad Nacional de Cordoba (Argentina) University of
Nebraska-Lincoln, and University of Sao Paulo (Brazil), utilized PLA (Polyvivo #
AP078) from PolySciTech (www.polyscitech.com)
as part of a microparticle system for delivery of polylysine as a treatment of
pancreatic cancer. This research holds promise for providing treatment options
for this fatal disease. Read more: Merari T. Chevalier, Mónica C. García,
Daniela Gonzalez, Sandro M. Gomes-Filho, Daniela S. Bassères, Hernan Farina
& Vera A. Alvarez (2017): Preparation, characterization and in vitro
evaluation of ε-polylysine-loaded polymer blend microparticles for potential
pancreatic cancer therapy, Journal of Microencapsulation, DOI:
10.1080/02652048.2017.1370028 (http://dx.doi.org/10.1080/02652048.2017.1370028)
“Peptide active ingredients show great promise
regarding the treatment of various health-endangering diseases. It is reported
that L-lysine inhibits the proliferation of several tumour lines in vitro and
in vivo. However, proteins and peptide drugs possess certain disadvantages such
as in vivo instability and short biological half-life. On the grounds that drug
delivery systems can overcome a wide spectrum of bioactive compounds issues, a
biopolymeric blend-based microparticulated system capable of delivering
ε-polylysine (PLL) was developed. PLL-loaded poly((L)Lactic
acid)/poly(D,L-Lactide)-co-poly(ethylene glycol)-based microparticles
(PLL-PB-MPs) were prepared and fully characterised exhibiting a narrow size
distribution (1.2 ± 0.12 µm), high loading efficiency (81%) and improved
thermal stability (Td from 250 °C to 291 °C). The cytotoxicity and
antiproliferative effect of PLL-PB-MPs in pancreatic adenocarcinoma cell lines
BxPC3 and MIA PaCa-2 were confirmed. Due to their physicochemical and
biopharmaceutical properties, PB-MPs constitute a promising carrier to deliver
bioactive peptides. Keywords: Biopolymers, ε-polylysine, microparticles,
polylactic acid”
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