One of the major contributing factors to morbidity and
death from brain cancer and other neurodegenerative disorders is the
inflammation brought on within the brain tissue itself. This leads to swelling,
oxidation, and potentially death. Typically treating any ailment that affects
the brain is difficult as relatively few medicinal compounds cross from the
blood stream into the brain tissue (the blood-brain-barrier). Nanotechnology
can be used to improve this however. Recently, researchers at Kent State
University and Northeast Ohio Medical University used mPEG-P(DL)La (PolyVivo
AK021) from PolySciTech (www.polyscitech.com)
to generate a delivery system for simvastatin to protect against
neuroinflammation. This research holds promise to reduce damage caused by
brain-tumors as well as other diseases implicated with inflammation of neural
tissue. Read more: Manickavasagam, Dharani, Kimberly Novak, and Moses O.
Oyewumi. "Therapeutic Delivery of Simvastatin Loaded in PLA-PEG
Polymersomes Resulted in Amplification of Anti-inflammatory Effects in
Activated Microglia." The AAPS Journal 20, no. 1 (2018): 18. https://link.springer.com/article/10.1208/s12248-017-0176-3
Blog dedicated to answering technical questions in an open format relating to PolySciTech (A division of Akina, Inc.) products.
Thursday, December 21, 2017
mPEG-PLA from PolySciTech used in development of nanoparticle treatment to protect brain tissue from inflammation damage
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