Several diseases and conditions are associated with an
excessive immune response which leads to inflammation that can damage tissue.
There are medicines available which can reduce the immune response (e.g.
anti-histamines, steroidal anti-inflammatories) however, these all have
side-effects due to their relatively non-specific nature in globally preventing
immune response. The immune system itself has a built-in regulatory mechanism
which acts through regulatory T-cells that act to reduce immune response and
improve the recognition of antigens as ‘self.’ A more effective and therapeutic
strategy is to provide factors which promote the formation and recruitment of
regulatory t-cells to a site of inflammation. Recently, researchers at The
University of Pittsburgh used mPEG-PLGA (PolyVivo AK037) from PolySciTech (www.polyscitech.com) to create a
microparticle designed to release pro-regulatory-t-cell factors into the eye as
a means to reduce localized inflammation by promoting the body’s own feedback
system to control the immune response. This research holds promise not only to
treat ocular diseases, but to be applied to other disease in which excessive
immune response is implicated. Read more: Ratay, Michelle L., Stephen C. Balmert,
Abhinav P. Acharya, Ashlee C. Greene, Thiagarajan Meyyappan, and Steven R.
Little. "TRI Microspheres prevent key signs of dry eye disease in a
murine, inflammatory model." Scientific Reports 7, no. 1 (2017): 17527. https://www.nature.com/articles/s41598-017-17869-y
Blog dedicated to answering technical questions in an open format relating to PolySciTech (A division of Akina, Inc.) products.
Tuesday, December 19, 2017
mPEG-PLGA from PolySciTech used in development of microparticle-based delivery system for regulatory T-cell induction factors as an anti-inflammatory therapy
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