As a general rule, it is very difficult to have a
material which adheres well to biological tissues. Biological tissues are warm,
wet, and typically covered with a coating of proteins which tend to reduce
adhesion. This makes designing adhesives for them very difficult. For tissue
engineering applications it is critical that whatever scaffold or patch is
applied, remains well-adhered to the tissue for it to work. The adhesive must also
be biocompatible. Interestingly, a solution for bioadhesion has presented
itself in nature from barnacles/mussels, which secrete an incredibly adhesive
biopolymer to hold onto rocks. Recently, researchers at University of Texas at
Arlington, used PLGA (PolyVivo AP154) from PolySciTech (www.polyscitech.com)
to create nanoparticles to improve the bioadhesion of barnacle/mussel-inspired alginate-dopa
hydrogels. This research holds promise for improved tissue engineering patches
and scaffolds to treat wounds and defects. Read more: Pandey, Nikhil, Amirhossein
Hakamivala, Cancan Xu, Prashant Hariharan, Boris Radionov, Zhong Huang, Jun
Liao et al. "Biodegradable Nanoparticles Enhanced Adhesiveness of Mussel‐Like Hydrogels at Tissue
Interface." Advanced healthcare materials (2017). http://onlinelibrary.wiley.com/doi/10.1002/adhm.201701069/full
Blog dedicated to answering technical questions in an open format relating to PolySciTech (A division of Akina, Inc.) products.
Monday, December 18, 2017
PLGA from PolySciTech used in developing Bioadhesive hydrogels for tissue-engineering applications
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