PLGA-PEG-PLGA thermogel from PolySciTech used in development of highly-controlled microwave ablation technique
Amongst cancer treatments, ablation (the application of
heat, cold, or chemicals in a minimally invasive manner directly to the tumor) has
gained attention as a method to treat cancer without the systemic damage of
chemotherapy or the invasive injuries from standard surgery. One of these
techniques, microwave thermal ablation, works by using microwave energy to
locally heat the tumor which kills the cancer while minimally affecting
surrounding tissues. Recently, Researchers at Brown University/Rhode Island
Hospital utilized PolyVivo (AK088) from PolySciTech (www.polyscitech.com) to develop a
cesium-salt loaded thermogel which acted to increase the local heating in the
vicinity of the tumor improving the effectiveness of thermal ablation. They
tested these in an animal model and found the method to be highly effective with
minimal side effects. This research holds promise to improve therapeutic
options for tumor treatment with minimal side effects. Read more: Park, William
Keun Chan, Aaron Wilhelm Palmer Maxwell, Victoria Elizabeth Frank, Michael
Patrick Primmer, Jarod Brian Paul, Scott Andrew Collins, Kara Anne Lombardo et
al. "The in vivo performance of a novel thermal accelerant agent used for
augmentation of microwave energy delivery within biologic tissues during
image-guided thermal ablation: a porcine study." International Journal of
Hyperthermia 34, no. 1 (2018): 11-18. http://www.tandfonline.com/doi/abs/10.1080/02656736.2017.1317367
“Abstract: Objectives: To investigate the
effects of a novel caesium-based thermal accelerant (TA) agent on ablation zone
volumes following in vivo microwave ablation of porcine liver and skeletal
muscle, and to correlate the effects of TA with target organ perfusion.
Materials and methods: This prospective study was performed following
institutional animal care and use committee approval. Microwave ablation was
performed in liver and resting skeletal muscle in eight Sus scrofa domesticus
swine following administration of TA at concentrations of 0 mg/mL (control),
100 mg/mL and 250 mg/mL. Treated tissues were explanted and stained with
triphenyltetrazolium chloride (TTC) for quantification of ablation zone
volumes, which were compared between TA and control conditions. Hematoxylin and
eosin (H&E) staining was also performed for histologic analysis. General
mixed modelling with a log-normal distribution was used for all quantitative
comparisons (p = 0.05). Results: A total of 28 ablations were performed in the
liver and 18 in the skeletal muscle. The use of TA significantly increased
ablation zone volumes in a dose-dependent manner in both the porcine muscle and
liver (p < 0.01). Both the absolute mean ablation zone volume and percentage
increase in ablation zone volume were greater in the resting skeletal muscle
than in the liver. In one swine, a qualitative mitigation of heat sink effects
was observed by TTC and H&E staining. Non-lethal polymorphic ventricular
tachycardia was identified in one swine, treated with intravenous amiodarone.
Conclusions: The use of a novel TA agent significantly increased mean ablation
zone volumes following microwave ablation using a porcine model. The
relationship between TA administration and ablation size was dose-dependent and
inversely proportional to the degree of target organ perfusion, and a
qualitative reduction in heat-sink effects was observed. Keywords: Image-guided
thermal ablation, thermal accelerant, augmentation of microwave energy,
complete ablation, the heat sink effect”
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