“Theranostic” is a term which combines ‘therapy’ and ‘diagnostic’
into a single word. In the realm of cancer research, it is a highly-sought
after property for any regimen as cancer is difficult to diagnose, locate, and
treat. Nanoparticles which can be targeted towards the cancerous lesions and
render them either visible or act as ultrasound/electromagnetic contrast agents
have great value in locating and diagnosing the cancer while nanoparticles which
deliver chemotherapeutic agents can be useful for treating cancer. Recently,
researchers working jointly at Yangzhou University and Soochow University
(China) used PLGA (AP040) from PolySciTech (www.polyscitech.com)
to develop nanoparticles which were decorated with gold nanoparticles (act as
contrast agents as well as photosensitizers) and were loaded with doxorubicin (a
chemotherapeutic agent). These particles were tested and found to be effective
both at locating cancer as well as treating it. This research holds promise to
provide for both improved diagnosis and treatment of cancer. Read more: Xi,
Juqun, Wenjuan Wang, Lanyue Da, Jingjing Zhang, Lei Fan, and Lizeng Gao.
"Au-PLGA hybrid nanoparticles with catalase-mimicking and near-infrared
photothermal activities for photoacoustic imaging-guided cancer therapy."
ACS Biomaterials Science & Engineering (2018). http://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.7b00901
“Imaging-guided diagnosis and therapy has been highlighted
in the area of nanomedicines. However, integrating multiple functions with high
performance in one theranostic (“all-in-one”) still presents considerable
challenges. Here, “all-in-one” nanoparticles with drug-loading capacity,
catalase-mimetic activity, photoacoustic (PA) imaging ability and photothermal
properties were prepared by decorating Au nanoparticles on doxorubicin (DOX)
encapsulated poly(lactic-co-glycolic acid) (PLGA) vehicle. The results revealed
that the as-prepared Au-PLGA hybrid nanoparticles possessed high photothermal
conversion efficiency of up to approximately 69.0%, meanwhile their strong
acoustic generation endowed them with efficient PA signal sensing for cancer
diagnosis. On an 808 nm laser irradiation, the O2 generation, DOX release
profile and reactive oxygen species (ROS) level were all improved, which were
beneficial to relieving tumor hypoxia and enhanced the cancer chemo/PTT
combined therapy. Overall, the multifunctional Au-PLGA hybrid nanoparticles
with these integrated advantages shows promise in PA imaging-guided diagnosis
and synergistic tumor ablation. Keywords: Au-PLGA hybrid nanoparticles;
catalase-mimicking activity chemo/photothermal therapy; photoacoustic imaging”
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