There are many different types of ‘light’ beyond the visible
spectrum. One example is near-infrared (~700-1000 nm), which is of lower frequency
than visible red light. This form of light has the unique capability to
penetrate through tissue. This feature is typically applied in tandem with a
fluorescent dye for imaging, however it can also be applied with a photothermal
agent to cause localized heating in a specific region, such as the tissue
immediately surrounding a tumor. Recently, researchers at the Chinese Academy
of Sciences and the City University of Hong Kong used PLA-PEG-PLA thermogel
(Polyvivo AK100) from PolySciTech (www.polyscitech.com)
to generate a near-infrared responsive photothermal therapy gel system. This
research holds promise for the development of novel therapeutic options for
cancer treatment. Read more: Shao, Jundong, Changshun Ruan, Hanhan Xie, Zhibin
Li, Huaiyu Wang, Paul K. Chu, and Xue-Feng Yu “Black-Phosphorus-Incorporated
Hydrogel as a Sprayable and Biodegradable Photothermal Platform for
Postsurgical Treatment of Cancer” Adv.
Sci. 2018, 1700848, 3 March 2018, 10.1002/advs.201700848 http://onlinelibrary.wiley.com/doi/10.1002/advs.201700848/full
“Abstract: Photothermal therapy (PTT) is a fledgling
therapeutic strategy for cancer treatment with minimal invasiveness but
clinical adoption has been stifled by concerns such as insufficient
biodegradability of the PTT agents and lack of an efficient delivery system.
Here, black phosphorus (BP) nanosheets are incorporated with a thermosensitive
hydrogel [poly(d,l-lactide)-poly(ethylene glycol)-poly(d,l-lactide)
(PDLLA-PEG-PDLLA: PLEL)] to produce a new PTT system for postoperative
treatment of cancer. The BP@PLEL hydrogel exhibits excellent near infrared
(NIR) photothermal performance and a rapid NIR-induced sol–gel transition as
well as good biodegradability and biocompatibility in vitro and in vivo. Based
on these merits, an in vivo PTT postoperative treatment strategy is
established. Under NIR irradiation, the sprayed BP@PLEL hydrogel enables rapid
gelation forming a gelled membrane on wounds and offers high PTT efficacy to
eliminate residual tumor tissues after tumor removal surgery. Furthermore, the
good photothermal antibacterial performance prevents infection and this
efficient and biodegradable PTT system is very promising in postoperative
treatment of cancer.”
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