A valuable tool for wound-healing and surgical
procedures is tissue adhesives which can bind tissues together and allow them
to regrow. Due to the potential for infection, it is desirable for these
adhesives to have antibiotic properties. Recently, researchers at Pennsylvania
State University, Zhejiang Wanli University, Harbin Engineering University, and
Jiangxi Provincial Children’s Hospital used PLGA (PolyVivo AP154) from
PolySciTech (www.polyscitech.com)
to act as a biocompatibility control for testing the cytotoxicity of their
developed systems. This research holds promise to improve would healing and
prevent infections. Read more: Guo, Jinshan, Wei Sun, Jimin Peter Kim, Xili Lu,
Qiyao Li, Min Lin, Oliver Mrowczynski et al. "Development of
tannin-inspired antimicrobial bioadhesives." Acta Biomaterialia (2018). https://www.sciencedirect.com/science/article/pii/S1742706118301284
“Abstract: Tissue adhesives play an important role in
surgery to close wounds, seal tissues, and stop bleeding, but existing
adhesives are costly, cytotoxic, or bond weakly to tissue. Inspired by the
water-resistant adhesion of plant-derived tannins, we herein report a new
family of bioadhesives derived from a facile, one-step Michael addition of
tannic acid and gelatin under oxidizing conditions and crosslinked by silver
nitrate. The oxidized polyphenol groups of tannic acid enable wet tissue
adhesion through catecholamine-like chemistry, while both tannic acid and
silver nanoparticles reduced from silver nitrate provide antimicrobial sources
inherent within the polymeric network. These tannin-inspired gelatin
bioadhesives are low-cost and readily scalable and eliminate the concerns of
potential neurological effect brought by mussel-inspired strategy due to the
inclusion of dopamine; variations in gelatin source (fish, bovine, or porcine)
and monomer feeding ratios resulted in tunable gelation times (36 s to 8 min),
controllable degradation (up to 100% degradation within a month), considerable
wet tissue adhesion strengths (up to 3.7 times to that of fibrin glue),
excellent cytocompatibility, as well as antibacterial and antifungal
properties. The innate properties of tannic acid as a natural phenolic
crosslinker, molecular glue, and antimicrobial agent warrant a unique and
significant approach to bioadhesive design. Keywords: tannin; polyphenol;
gelatin; bioadhesives; antimicrobial; medical device”
-
No comments:
Post a Comment