PolySciTech polymers used in recent patent regarding a new manufacturing technique to generate nanoparticles

There are many different methods to generate nanoparticles and there are continuously new methods developed in this field. A recent patent by Phosphorex describes many PolySciTech (www.polyscitech.com) polymers for use in making nanoparticles including AV017 (mPEG-PLA-FKR648), AV18 (mPEG-PLGA-FKR560), AV016 (PLA-Fluorescein), AV013 (PLA-FPR648), AV015 (PLGA-FKR648), AV001 (PLGA-Fluorescein), AV006 (PLGA-FPI749), and AV011 (PLGA-Rhodamine B), AI016 (PLGA-NH2), AI025 (PLGA-SH), AI096 (PLGA-NHS), AI052 (PLGA-PEG-Mal), AI078 (PLGA-PEG-COOH), AI087 (PCL-NH2), AI021 (NH2-PLGA-NH2), AI086 (mPEG-PLGA-NH2). This research holds promise for further development of nanoparticle based technology. Read more: Wu, Bin. "Extremely small nanoparticles of degradable polymers." U.S. Patent Application 15/897,371, filed January 24, 2019. https://patents.google.com/patent/US20190021999A1/en

“Summary: The invention described herein is partly based on the realization that, to encapsulate a water-soluble drug, a double emulsion process is commonly used, which requires the polymer (e.g., PLGA polymer) to be dissolved in a water immiscible solvent, whereas the solvents used in the precipitation method are generally water miscible. Thus, to solve this problem, the current invention provides a method of synthesizing small polymeric nanoparticles by utilizing a single emulsion technique, described herein. This invention also provides a method of synthesizing small polymeric nanoparticles by utilizing a double emulsion technique, described herein. This invention also provides a method of synthesizing small polymeric nanoparticles loaded with therapeutic agents by utilizing a single emulsion technique, described herein. This invention also provides a method of synthesizing small polymeric nanoparticles loaded with therapeutic agents by utilizing a double emulsion technique, described herein. This invention also provides a composition of small polymeric nanoparticles, described herein. This invention also provides a composition of small polymeric nanoparticles loaded with therapeutic agents, described herein. This invention also provides a composition of small polymeric nanoparticles coated with non-therapeutic agents, described herein.”

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