Thermogels from PolySciTech used in research on 3D printing of hydrogel substrates

Conventional 3D printing relies on heating a plastic above its melting point and then extruding it onto a cooled platform. Conversely, 3D printing with a Thermogel requires placing a cooled Thermogel solution onto a heated plate to form the gel. Recently, researchers at Purdue University and Korea Institute of Industrial Technology used NIPAM-co-MMA (AO023) from PolySciTech (www.polyscitech.com) to create 3-D printable hydrogel matrix. This research holds promise to enable generation of drug delivery systems and tissue scaffolds for biomedical applications in the future. Read more: Cheng, Cih, Yoon Jae Moon, Samuel Haidong Kim, Yong-Cheol Jeong, Jun Young Hwang, George T-C. Chiu, and Bumsoo Han. "Water-matrix interaction at the drop-drop interface during drop-on-demand printing of hydrogels." International Journal of Heat and Mass Transfer 150 (2020): 119327. https://www.sciencedirect.com/science/article/pii/S0017931019342085

“Highlights: Drop-drop interactions during hydrogel printing are explained considering water-matrix interactions within hydrogel drops printed. A similarity mechanism of water-matrix interaction, and associated dimensionless parameter are proposed. The water-matrix interactions at the drop-drop interfance affect the microstructure of hydrogel drops printed. Abstract: Hydrogel-based soft materials have been used in numerous applications in healthcare, food, pharmaceutical, and cosmetic industries. Manufacturing hydrogels whose functional properties and compositions are voxelized at superior spatial resolutions can significantly improve current applications as well as will enable a new generation of soft materials. However, it remains challenging to control the structure and composition of soft materials reliably. In this context, the drop-on-demand (DOD) printing of hydrogels shows excellent potential to address this manufacturing challenge. Despite this potential, a lack of mechanistic understanding of the behavior of printed hydrogel drops makes it challenging to design and optimize DOD printing protocols for a wide variety of hydrogels. In particular, the curing of hydrogel drops, which requires dehydration of printed hydrogel drops, is poorly understood. In this study, thus, a hypothesis was postulated and tested that water-matrix interaction at drop-drop interfaces during curing processes determine the quality of hydrogels printed. Both computational and experimental studies were performed to establish a mechanism of the water-matrix interaction within printed hydrogel drops. The results were further discussed to establish a dimensionless similarity parameter that can characterize water transports during the hydrogel dehydration process. Keywords: Water transport Evaporation Interstitial water Poroelastic material 3D printing”

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