PLGA-PEG-PLGA from PolySciTech used in development of spinal-column repair gel

Providing the correct scaffolding and conditions can enable the regrowth of damaged tissue and organs. This can be used to heal injuries after trauma or disease including paralysis caused by spinal column damage. Recently, researchers at Zhejiang University and Hangzhou Dajiangdong Hospital (China) used PLGA-PEG-PLGA Thermogel (AK012) from PolySciTech (www.polyscitech.com) to create a system for repair of spinal cord injuries. This research holds promise to improve available treatments for paralysis in the future. Read more: Gong, Zhe, Chenggui Wang, Licheng Ni, Liwei Ying, Jiawei Shu, Jingkai Wang, Chao Yu et al. "An injectable recombinant human milk fat globule–epidermal growth factor 8–loaded copolymer system for spinal cord injury by reducing inflammation through NF-κB pathway and neuronal cell death." Cytotherapy (2020). https://www.sciencedirect.com/science/article/pii/S1465324920300360

“Abstract: Spinal cord injury (SCI) is a common disease and a major cause of paralysis, carrying much burden around the world. Despite the progress made with growth factors therapy, the response rate of acute SCI treatment still remains unsatisfactory, due largely to complex and severe inflammatory reactions. Herein, we prepare a MFG-E8–loaded copolymer system–based anti-inflammation therapy for SCI treatment. It is shown that the MFG-E8–loaded copolymer system can decrease pro-inflammatory cytokine expression and neuron death. In a rat model of crush-caused SCI, the copolymer system shows significant therapeutic efficacy by ameliorating inflammation, decreasing fibrotic scar, promoting myelin regeneration and suppressing overall SCI severity. Key Words inflammationmilk fat globule–epidermal growth factor 8poly- (DL-lactic acid co-glycolic acid)–polyethylene glycol–poly- (DL-lactic acid co-glycolic acid) copolymerspinal cord injury”

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