PLGA from PolySciTech used in development of treatment for MRSA infected wounds

Methicillin-resistant Staphylococcus aureus (MRSA) is a wound-infecting pathogen that leads to significant causes of morbidity and mortality which is difficult to treat due to its resistance against most common antibiotics. Recently, researchers at Pusan National University (Korea) used PLGA (AP037) from PolySciTech (www.poyscitech.com) to develop nitrosoglutathione delivery nanoparticles to provide for treatment against wound infection. This research holds promise to provide for more effective treatments against MRSA infections in the future. Read more: Lee, Juho, Dongmin Kwak, Hyunwoo Kim, Jihyun Kim, Shwe Phyu Hlaing, Nurhasni Hasan, Jiafu Cao, and Jin-Wook Yoo. "Nitric Oxide-Releasing S-Nitrosoglutathione-Conjugated Poly (Lactic-Co-Glycolic Acid) Nanoparticles for the Treatment of MRSA-Infected Cutaneous Wounds." Pharmaceutics 12, no. 7 (2020): 618. 

https://www.mdpi.com/1999-4923/12/7/618 

“Abstract: S-nitrosoglutathione (GSNO) has emerged as a potent agent for the treatment of infected cutaneous wounds. However, fabrication of GSNO-containing nanoparticles has been challenging due to its high hydrophilicity and degradability. The present study aimed to fabricate nanoparticles using newly synthesized GSNO-conjugated poly(lactic-co-glycolic acid) (PLGA) (GSNO-PLGA; GPNPs). Since hydrophilic GSNO was covalently bound to hydrophobic PLGA, loss of GSNO during the nanoparticle fabrication process was minimized, resulting in sufficient loading efficiency (2.32% of GSNO, 0.07 μmol/mg of NO). Real-time NO release analysis revealed biphasic NO release by GPNPs, including initial burst release within 3 min and continuous controlled release for up to 11.27 h, due to the differential degradation rates of the –SNO groups located at the surface and inside of GPNPs. Since GPNPs could deliver NO more efficiently than GSNO in response to increased interaction with bacteria, the former showed enhanced antibacterial effects against methicillin-resistant Staphylococcus aureus (MRSA) at the same equivalent concentrations of NO. Finally, the facilitating effects of GPNPs on infected wound healing were demonstrated in MRSA-challenged full-thickness wound mouse model. Collectively, the results suggested GPNPs as an ideal nanoparticle formulation for the treatment of MRSA-infected cutaneous wounds. Keywords: S-nitrosoglutathione (GSNO); poly(lactic-co-glycolic acid) (PLGA); nitric oxide; nitric oxide-releasing nanoparticles; GSNO-conjugated PLGA; methicillin-resistant Staphylococcus aureus (MRSA); infected wound healing”