PEG-Chitosan from PolySciTech used in development of novel oral-delivery system

 

Oral dosage with pills, capsules, liquids or other formulations is significantly more convenient and less painful for the patient than parental injections. However, several drugs do not have good permeation across the intestinal mucosa or are destroyed in the stomach which limits their ability to be administered orally. Recently, researchers at Hacettepe University (Turkey) and University of Aalborg (Denmark) used PEG-Chitosan from PolySciTech (www.polyscitech.com) to create nanosystems for delivery of Aprepitant which is used to reduce nausea during chemotherapy. This research holds promise to improve the ease and convenience of medicines by enabling oral route. Read more: Erdoğar, Nazlı, Safiye Akkın, Thorbjorn T. Nielsen, Esin Özçelebi, Batuhan Erdoğdu, Emirhan Nemutlu, Alper B. İskit, and Erem Bilensoy. "Development of oral aprepitant-loaded chitosan–polyethylene glycol-coated cyclodextrin nanocapsules: formulation, characterization, and pharmacokinetic evaluation." Journal of Pharmaceutical Investigation (2021): 1-14. https://link.springer.com/article/10.1007/s40005-020-00511-x

“Abstract: Aprepitant (APRT), a selective neurokinin 1 antagonist, is clinically used in the prevention of acute and delayed chemotherapy-induced nausea and vomiting. The low solubility of APRT, which limits its oral bioavailability, is overcome by nanonization. This study aimed to design and evaluate novel in vitro and in vivo chitosan (CS)–polyethylene glycol (PEG)-coated cyclodextrin (CD) nanoparticles and nanocapsules to enhance the solubility and oral bioavailability of APRT. Methods: A novel amphiphilic CD derivative with alkyl chains of 9 carbons (ACD-C9) was synthesized to form nanoparticles and nanocapsules by using nanoprecipitation. The nanocarriers were coated with the CS–PEG conjugate to increase their biological interaction with cell membranes via the positive charge and penetration-enhancer properties of CS. The nanosystems were evaluated for particle size, surface charge, drug loading, imaging, release, cell culture, and oral bioavailability in an animal model. Results: The CS–PEG-coated nanosystems had particle size of 400–550 nm, a narrow polydispersity index, positive zeta potential, and favorable drug loading (55 and 93% for nanoparticles and nanocapsules, respectively). Sustained release was observed within 24 h. Blank nanoparticles and nanocapsules were non-cytotoxic against the L929 cell line. The intestinal permeability of the nanocarriers was 2–threefold (2-3 fold) higher than that of the drug solution, and the nanocapsules afforded the highest APRT permeability through Caco-2 cells. Oral bioavailability studies in rats revealed comparable degree of drug absorption between nanocapsules and commercial APRT products. Conclusion: Oral ACD-C9 nanocapsules have the potential for the treatment of chemotherapy-induced nausea and vomiting.”