PLGA from PolySciTech Used in development of antibacterial surfaces for surgical implants to prevent infection

 

A common problem with surgical interventions is the potential for bacterial infections to grow and spread particularly along the surfaces of implanted materials. In addition to conventional asceptic surgical practices the use of surfaces which release antibiotics and have antimicrobial properties can prevent such infections. Recently, researchers at Università di Perugia (Italy) used PLGA (AP020) from PolySciTech (www.polyscitech.com) along with zirconium phosphate to produce polymeric composites which released antibacterial and other compounds to prevent infection. This research holds promise to reduce surgery-related infections. Read more: Pica, Monica, Nicla Messere, Tommaso Felicetti, Stefano Sabatini, Donatella Pietrella, and Morena Nocchetti. "Biofunctionalization of Poly (lactide-co-glycolic acid) Using Potent NorA Efflux Pump Inhibitors Immobilized on Nanometric Alpha-Zirconium Phosphate to Reduce Biofilm Formation." Materials 14, no. 3 (2021): 670. https://www.mdpi.com/982146

“Abstract: Polymeric composites, where bioactive species are immobilized on inorganic nanostructured matrix, have received considerable attention as surfaces able to reduce bacterial adherence, colonization, and biofilm formation in implanted medical devices. In this work, potent in-house S. aureus NorA efflux pump inhibitors (EPIs), belonging to the 2-phenylquinoline class, were immobilized on nanometric alpha-zirconium phosphate (ZrP) taking into advantage of acid-base or intercalation reactions. The ZrP/EPI were used as filler of poly(lactide-co-glycolic acid) (PLGA) to obtain film composites with a homogeneous distribution of the ZrP/EPI fillers. As reference, PLGA films loaded with ZrP intercalated with thioridazine (TZ), that is recognized as both a NorA and biofilm inhibitor, and with the antibiotic ciprofloxacin (CPX) were prepared. Composite films were characterized by X-ray diffraction, scanning electron microscopy, and thermogravimetric analysis. The ability of the composite films, containing ZrP/EPI, to inhibit biofilm formation was tested on Staphylococcus aureus ATCC 29213 and Staphylococcus epidermidis ATCC 12228, and it was compared with that of the composite loaded with ZrP/TZ. Finally, the antibacterial activity of CPX intercalated in ZrP was evaluated when used in combination with ZrP/EPI in the PLGA films. Keywords: zirconium phosphate; PLGA; Efflux pump inhibitors; biofilm inhibition; composites”