PLGA from PolySciTech used in development of pH responsive platinum loaded nanoparticle for treatment of ovarian cancer.

 

Ovarian cancer is a very common and lethal cancer which ranks fifth in cancer deaths amongst women (cancer.org). Recently, researchers at the City University of New York, Icahn School of Medicine at Mount Sinai, and Rudy Ruggles Research Institute used PLGA (cat# AP081) from PolySciTech division of Akina, Inc. (www.polyscitech.com) to create a pH-responsive nanoparticle with a PLGA-platinum core for treatment of ovarian cancer. This research holds promise to improve therapies against this often lethal disease. Read more: Wlodarczyk, Marek T., Sylwia A. Dragulska, Ying Chen, Mina Poursharifi, Maxier Acosta Santiago, John A. Martignetti, and Aneta J. Mieszawska. "Pt (II)-PLGA Hybrid in a pH-Responsive Nanoparticle System Targeting Ovarian Cancer." Pharmaceutics 15, no. 2 (2023): 607. https://www.mdpi.com/2130320

“Abstract: Platinum-based agents are the main treatment option in ovarian cancer (OC). Herein, we report a poly(lactic-co-glycolic acid) (PLGA) nanoparticle (NP) encapsulating platinum (II), which is targeted to a cell-spanning protein overexpressed in above 90% of late-stage OC, mucin 1 (MUC1). The NP is coated with phospholipid-DNA aptamers against MUC1 and a pH-sensitive PEG derivative containing an acid-labile hydrazone linkage. The pH-sensitive PEG serves as an off–on switch that provides shielding effects at the physiological pH and is shed at lower pH, thus exposing the MUC1 ligands. The pH-MUC1-Pt NPs are stable in the serum and display pH-dependent PEG cleavage and drug release. Moreover, the NPs effectively internalize in OC cells with higher accumulation at lower pH. The Pt (II) loading into the NP was accomplished via PLGA-Pt (II) coordination chemistry and was found to be 1.62 wt.%. In vitro screening using a panel of OC cell lines revealed that pH-MUC1-Pt NP has a greater effect in reducing cellular viability than carboplatin, a clinically relevant drug analogue. Biodistribution studies have demonstrated NP accumulation at tumor sites with effective Pt (II) delivery. Together, these results demonstrate a potential for pH-MUC1-Pt NP for the enhanced Pt (II) therapy of OC and other solid tumors currently treated with platinum agents. Keywords: nanoparticles; pH-sensitive; ovarian cancer; platinum therapy; in vivo imaging”

Video: https://youtu.be/lgf74nec28A