Fluorescent PLGA-Rhodamine from PolySciTech used in development of dual-loaded nanoparticles for treatment of skin disease

 

Inflammatory Skin Conditions including eczema, seborrheic dermatitis, and psoriasis are extremely common and affect more than 27 million American adults. Ideally these can be treated using a localized or targeted therapy to reduce systemic side-effects. Researchers at Université Paris-Saclay, Université Paris-Cité, and Sorbonne Université (CNRS, Inserm, SFR-UMS-IPSIT) used PLGA-Rhodamine B (AV011) from PolySciTech division of Akina, Inc. (www.polyscitech.com) to create fluorescently traceable nanoparticles for stabilizing an emulsion. This research holds promise to provide for dual-drug loaded formulations for treatment of skin diseases. Read more: Beladjine, Mohamed, Claire Albert, Maxime Sintès, Ghozlene Mekhloufi, Claire Gueutin, Valérie Nicolas, Alexis Canette et al. "Pickering Emulsions Stabilized With Biodegradable Nanoparticles For The Co-Encapsulation Of Two Active Pharmaceutical Ingredients." International Journal of Pharmaceutics (2023): 122870. https://www.sciencedirect.com/science/article/pii/S0378517323002909

“Abstract: Innovative Pickering emulsions co-encapsulating two active pharmaceutical ingredients (API) were formulated for a topical use. An immunosuppressive agent, either cyclosporine A (CysA) or tacrolimus (TAC), was encapsulated at high drug loading in biodegradable and biocompatible poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NP). These NP stabilized the oil droplets (Miglyol) containing an anti-inflammatory drug, calcitriol (CAL). The influence of the API on the physico-chemical properties of these emulsions were studied. Emulsions formulated with or without API had a similar macroscopic and microscopic structure, as well as interfacial properties, and they exhibited a good stability for at least 55 days. The emulsions did not alter the viability of human keratinocytes (HaCaT cell line) after 2 and 5 days of exposure to NP concentrations equivalent to efficient API dosages. Thus, these new Pickering emulsions appear as a promising multidrug delivery system for the treatment of chronical inflammatory skin diseases. Keywords: calcitriol co-encapsulation cyclosporine A interfacial properties nanoparticles Pickering emulsion PLGA tacrolimus skin diseases stability”


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