PLGA-PEG-NH2 from PolySciTech used in research on protein corona on nanoparticle transport

 

In the human body nanoparticles naturally adsorb proteins and this affects the transport of the particles inside the human body. Researchers at University of Technology Sydney, University of Adelaide, and The University of Melbourne used PLGA-PEG-NH2 (cat# AI169) from PolySciTech Division of Akina, Inc. (www.polyscitech.com) to analyze the effects of protein formation on nanoparticle transport. This research can improve drug delivery approaches in the future. Read more: Rennie, Claire, Nabila Morshed, Matthew Faria, Lyndsey Collins-Praino, and Andrew Care. "Nanoparticle Association with Brain Cells Is Augmented by Protein Coronas Formed in Cerebrospinal Fluid." Molecular Pharmaceutics (2025). https://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.4c01179

“Neuronanomedicine harnesses nanoparticle technology for the treatment of neurological disorders. An unavoidable consequence of nanoparticle delivery to biological systems is the formation of a protein corona on the nanoparticle surface. Despite the well-established influence of the protein corona on nanoparticle behavior and fate, as well as FDA approval of neuro-targeted nanotherapeutics, the effect of a physiologically relevant protein corona on nanoparticle-brain cell interactions is insufficiently explored. Indeed, less than 1% of protein corona studies have investigated protein coronas formed in cerebrospinal fluid (CSF), the fluid surrounding the brain. Herein, we utilize two clinically relevant polymeric nanoparticles (PLGA and PLGA-PEG) to evaluate the formation of serum and CSF protein coronas. LC–MS analysis revealed distinct protein compositions, with selective enrichment/depletion profiles. Enhanced association of CSF precoated particles with brain cells demonstrates the importance of selecting physiologically relevant biological fluids to more accurately study protein corona formation and subsequent nanoparticle-cell interactions, paving the way for improved nanoparticle engineering for in vivo applications.”

PLGA-PEG-NH2 (Cat# AI169): https://akinainc.com/polyscitech/products/polyvivo/index.php?highlight=AI169#h

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