Polycaprolactone from PolySciTech used in development of Cell scaffold.

 

Vascular grafts are a way to regrow damaged blood vessels. Researchers at University of Colorado used PCL (AP257) from PolySciTech Division of Akina, Inc. (www.polyscitech.com) to develop scaffolds for graft repair. This research holds promise to improve healing of damaged tissues. Read more: Battistella, Aurora, Morgan Linger, Richard D. Johnson, Anna Sallee, Rajan Jain, Bridget Antreasian, Yifu Ding, and Wei Tan. "Fabrication of Polymer Blend Vascular Grafts with Enhanced Mechanical Properties and Rapid Cell Infiltration: Influence of Micro/Nanostructure, Polymer Composition, and Post-Processing on Pore Architecture And Bioengineered Environment." Nanostructure, Polymer Composition, and Post-Processing on Pore Architecture And Bioengineered Environment. https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5179106

“Abstract: Vascular grafts are often used to treat cardiovascular diseases. Desired properties of next-generation graft materials include artery-like mechanics, clinically feasible manufacturing processes, and a bioactive interface that facilitates rapid and deep infiltration of neighboring cells to support tissue regeneration. These requirements inspired the design, fabrication, and post-processing of our graft materials. In terms of material design, we evaluated the performance of three microfiber graft materials composed of a hydrophobic polymer and photo-clickable, 4-arm thiolated polyethylene glycol-norbornene (PEG-NB). The materials included two coaxially nanostructured fiber designs, each featuring a PEG-NB sheath and different cores—polycaprolactone (PCL) and polycaprolactone-co-lactic acid (PLCL), respectively—and a mixed composition created by directly blending the sheath and core solutions during electrospinning. For post-processing, the constructs were either air-dried or freeze-dried. Surface morphology was assessed using scanning electron microscopy, while mechanical properties were characterized through tensile testing and dynamic mechanical analysis. Subcutaneous implants were evaluated at 1, 4, and 16 weeks using histological, immunofluorescent, and multiphoton microscopy analyses to examine cellular distribution, material structure, and tissue remodeling. Results showed that the freeze-drying post-processing method enhanced overall porosity, stiffness, and ultimate tensile strength. Among all tested conditions, the freeze-dried core-sheath structure with PCL most closely matched the mechanical properties of native vessels. Using PLCL as a core material increased degradation and cell infiltration during the first month of subcutaneous studies. Ultimately, graft strength, porosity, and bioactivity were effectively modulated by the choice of core material and post-processing method. The distinct strengths of PCL and PLCL as a core polymer suggest that combining these materials could potentially optimize material degradation, cell infiltration and tissue remodeling along with mechanical performance.”

PCL (Cat# AP257): https://akinainc.com/polyscitech/products/polyvivo/index.php?highlight=AP257#h

Akina, Inc. launches new GMP manufacturing service available to outside customers https://www.akinainc.com/midwestgmp/

Corbion Purasorb® Polymers: https://akinainc.com/polyscitech/products/purasorb/

Ashland-TM Polymer Products: https://akinainc.com/polyscitech/products/ashland/