PLGA-PEG-biotin from PolySciTech used in testing of serum protein attachment to nanoparticles

 

A powerful tool is the ability for nanoparticles to specifically bind to receptors in-vivo for drug delivery. Researchers at University of Toronto, Imperial College of London, University of Washington, California Institute of Technology, and University of Waterloo used PLGA-PEG-Biotin (Cat# AI167) from PolySciTech Division of Akina, Inc. (www.polyscitech.com) to develop nanoparticles and test these along with many other configurations to determine the impact of serum binding. This research holds promise to improve drug delivery techniques in the future. Read more: Stordy, Benjamin P., Zahra Sepahi, Gabriel D. Patrón, Wei Yang, Alexander D. Goodson, Colin Blackadar, Anthony J. Tavares et al. "The Binding Affinities of Serum Proteins to Nanoparticles." Journal of the American Chemical Society (2025). https://pubs.acs.org/doi/abs/10.1021/jacs.5c02576



“Nanoparticles can be coated with targeting ligands to deliver medical agents to specific cells. Serum protein adsorption affects the binding of nanoparticles to target cells. We hypothesized that serum proteins and target receptors compete for binding to nanoparticles. We tested the serum protein binding affinity of 251 nanoparticle designs. Here, we discovered that the binding affinities of serum proteins and receptors to a nanoparticle determine whether it can bind to target cells. We developed and validated a quantitative metric, the binding ratio, to identify nanoparticle designs that can bind to targets in serum with 90% sensitivity and 88% specificity. Using the binding ratio as a numerical guideline for nanoparticle design enabled us to improve the efficiency of nanoparticle binding to target cellular receptors.”

PLGA-PEG-Biotin (Cat# AI167): https://akinainc.com/polyscitech/products/polyvivo/index.php?highlight=AI167#h

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