Near infrared (NIR) light is a form of long-wavelength light which can harmlessly pass through human tissue and be utilized to trigger actions inside the human body. Researchers at University of Massachusetts Dartmouth used PLGA (AP016) from PolySciTech Division of Akina, Inc. (www.polyscitech.com) to develop microparticles for NIR-triggered vancomycin delivery. This research holds promise to provide for precisely controlled delivery of drugs. Read more: Pokharel, Mishal, Abid Neron, Amit Kumar Dey, Aishwarya Raksha Siddharthan, Menaka Konara, Md Mainuddin Sagar, Tracie Ferreira, and Kihan Park. "Light-Responsive PLGA Microparticles for On-Demand Vancomycin Release and Enhanced Antibacterial Efficiency." Pharmaceutics 17, no. 8 (2025): 1007. https://www.mdpi.com/1999-4923/17/8/1007
“Abstract: Background: A precise drug delivery system enables the optimization of treatments with minimal side effects if it can deliver medication only when activated by a specific light source. This study presents a controlled drug delivery system based on poly(lactic-co-glycolic acid) (PLGA) microparticles (MPs) designed for the sustained release of vancomycin hydrochloride. Methods: The MPs were co-loaded with indocyanine green (ICG), a near-infrared (NIR) responsive agent, and fabricated via the double emulsion method.They were characterized for stability, surface modification, biocompatibility, and antibacterial efficacy. Results: Dynamic light scattering and zeta potential analyses confirmed significant increases in particle size and surface charge reversal following chitosan coating. Scanning electron microscopy revealed uniform morphology in uncoated MPs (1–10 μm) and irregular surfaces post-coating. Stability tests demonstrated drug retention for up to 180 days. Among formulations, PVI1 exhibited the highest yield (76.67 ± 1.3%) and encapsulation efficiency (56.2 ± 1.95%). NIR irradiation (808 nm) enhanced drug release kinetics, with formulation PVI4 achieving over 48.9% release, resulting in improved antibacterial activity. Chitosan-coated MPs (e.g., PVI4-C) effectively suppressed drug release without NIR light for up to 8 h, with cumulative release reaching only 10.89%. Without NIR light, bacterial colonies exceeded 1000 CFU; NIR-triggered release reduced them below 120 CFU. Drug release data fitted best with the zero-order and Korsmeyer–Peppas models, suggesting a combination of diffusion-controlled and constant-rate release behavior. Conclusions: These results demonstrate the promise of chitosan-coated NIR-responsive PLGA MPs for precise, on-demand antibiotic delivery and improved antibacterial performance. Keywords: near-infrared light; microparticles; antibiotic; drug delivery; controlled release; chitosan coating”
PLGA (https://akinainc.com/polyscitech/products/polyvivo/index.php?highlight=AP016#h)
Benchtop to Bedside with MidWest GMP https://www.akinainc.com/midwestgmp/
Corbion Purasorb® Polymers: https://akinainc.com/polyscitech/products/purasorb/
Ashland-TM Polymer Products: https://akinainc.com/polyscitech/products/ashland/
BPR Akina's Free Scientific Conference (West Lafayette, 4/29/26: (https://akinainc.com/bprconference/)
No comments:
Post a Comment