PLGA from PolySciTech used in development of hyaluronic-acid conjugated nanocarriers for colorectal cancer therapy

 

Colorectal cancer is the third most common cancer and it develops in the lower part of the large intestine. Researchers at Pusan National University used a series of PLGAs (AP037, AP040, AP082, and AP154) from Akina from PolySciTech Division of Akina, Inc. (www.polyscitech.com) to develop hyaluronic acid conjugated PLGA for colorectal cancer (CRC)-targeted nanoparticles. This research holds promise to treat this common and deadly disease. Read more: Lee, Juho, Dongmin Kwak, Hyunwoo Kim, Muneeb Ullah, Jihyun Kim, Muhammad Naeem, Seonghwan Hwang et al. "Elucidating a Tumor‐Selective Nanoparticle Delivery Mechanism at the Colorectal Lumen–Tumor Interface for Precise Local Cancer Therapy." Small 21, no. 9 (2025): 2409994. https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.202409994

“Although various colorectal cancer (CRC)-targeted nanoparticles have been developed to selectively deliver anticancer agents to tumor tissues, severe off-target side effects still persist due to unwanted systemic nanoparticle distribution, limiting the therapeutic outcome. Here, by elucidating a tumor-selective nanoparticle delivery mechanism occurring at the colorectal lumen–tumor interface, an alternative CRC-targeted delivery route is proposed, which enables highly tumor-selective delivery without systemic distribution, through direct drug delivery from the outside of the body (colorectal lumen) to tumors in the colorectum. Owing to the presence of accessible tumor-specific receptors such as CD44 at the colorectal lumen–tumor interface, but not at the colorectal lumen–normal tissue interface, colorectal luminal surface (CLS)-targeting ligand-functionalized nanoparticles selectively accumulate in CRC tissues without systemic distribution, resulting in successful local CRC therapy. The findings suggest that CLS-targeted lumen-to-tumor delivery can be a suitable strategy for highly CRC-specific drug delivery for precise local CRC therapy.”

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