PLA from PolySciTech used in development of brain-penetrating nanoparticle for treatment of neurological disorders.

 

Transport of medicines into the brain tissue is difficult due to the highly-selective Blood-Brain-Barrier. Researchers at Louisiana State University and Louisiana Tech University recently utilized Polylactide (Cat# AP047, https://akinainc.com/polyscitech/products/polyvivo/index.php?highlight=AP047#h) from PolySciTech division of Akina, Inc. (www.PolySciTech.com) in development of electrically activated particles for brain delivery. This research holds promise to provide for delivery of drugs to brain diseases. Read more: Roy, Salona, Umisha Siwakoti, Daniel Alday, Carlos Astete, Ethan McElveen, Ashok Sigdel, Fabio Del Piero, Cristina Sabliov, Elisa Castagnola, and Qi Cai. "On-demand, reversible blood-brain barrier opening via electrical activation of piezoelectric nanoparticles for targeted brain drug delivery." bioRxiv (2026): 2026-07. https://www.biorxiv.org/content/10.64898/2026.07.20.738792.abstract

“Delivering therapeutics to the brain remains one of the most persistent challenges in medicine, because the blood-brain barrier (BBB) excludes over 98% of small-molecule drugs and virtually all biologics from the central nervous system (CNS). We developed electrical BBB modulation (eBBB), an on-demand platform combining vascular-targeting poly-L-lactic acid nanoparticles with high-definition transcranial direct current stimulation to achieve spatially and temporally controlled BBB opening. eBBB produced localized, reversible increases in BBB permeability confined to the stimulated cortex, with the opening area tunable via electrode geometry. This transient window enhanced regional delivery of a small-molecule drug, full-length immunoglobulins, and adeno-associated viral vectors, which are cargo classes otherwise completely excluded by the intact BBB. Neurovascular unit architecture was preserved with no lasting histological damage. Integrating a biodegradable nanomaterial with a clinically evaluated stimulation technology, eBBB offers a programmable, minimally invasive strategy for regional CNS drug delivery across brain malignancies and neurological disorders.”

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