Tuesday, October 26, 2010

Diblock PEG-PLGA usage note

The below study highlights the capabilities for PEG-PLGA to be used for drug delivery nanoparticles. Check out http://www.polyvivo.com/ to learn more about these types of polymers. (note the below study did not necessarily use a PolySciTech product(s)).

"The development of long-circulating carriers capable of continuously delivering drugs intravenously provides a potential approach to achieve targeting of drugs to specific sites of action. In this research, polyethylene glycol (PEG)-coated nanospheres were prepared in a single step process using amphiphilic diblock and multiblock copolymers, and their drug encapsulation properties and release characteristics were investigated in vitro. The results obtained indicate that the parameters controlling drug release characteristics of these nanospheres are the chemical composition of their hydrophobic core (i.e. polyester or polyanhydride), as well as the molecular weight and surface density of their hydrophilic (i.e. PEG) chains"

M.T. Peracchia, R. Gref, Y. Minamitake, A. Domb, N. Lotan, R. Langer, PEG-coated nanospheres from amphiphilic diblock and multiblock copolymers: Investigation of their drug encapsulation and release characteristics. Journal of Controlled Release 46(3) (1997) 223-231. http://www.sciencedirect.com/science/article/B6T3D-3V2MYFP-1X/2/c7d6d5f390fc991fc9e3c0cee685810a
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