Tuesday, October 26, 2010

diblock PEG-PLGA usage note

The below study highlights the capabilities for PEG-PLGA to be used for drug delivery nanoparticles. Check out http://www.polyvivo.com to learn more about these types of polymers. (note the below study did not necessarily use a PolySciTech product(s)).

"Injectable nanoparticulate carriers have important potential applications such as site-specific drug delivery or medical imaging. Conventional carriers, however, cannot generally be used because they are eliminated by the reticulo-endothelial system within seconds or minutes after intravenous injection. To address these limitations, monodisperse biodegradable nanospheres were developed from amphiphilic copolymers composed of two biocompatible blocks. The nanospheres exhibited dramatically increased blood circulation times and reduced liver accumulation in mice. Furthermore, they entrapped up to 45 percent by weight of the drug in the dense core in a one-step procedure and could be freeze-dried and easily redispersed without additives in aqueous solutions. "

R. Gref, Y. Minamitake, M.T. Peracchia, V. Trubetskoy, V. Torchilin, R. Langer, Biodegradable long-circulating polymeric nanospheres. Science 263(5153) (1994) 1600-1603.
http://www.sciencemag.org/cgi/content/abstract/263/5153/1600
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