Friday, November 5, 2010

Degradation Rate

The below study elucidates the relative degradation rates of block copolymers with respect to their PEG-PLGA content. Check out http://www.polyvivo.com to learn more. (note the below study did not necessarily use a PolySciTech product(s). Please go to original source for fultext or follow the link below.)

The degradation behaviour of a new class of multi-block copolymers containing poly( -lactic-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) segments was studied under conditions mimicking those found in biological fluids. The dissolution times of the new PLGA-PEG multi-block copolymers mainly depend on the length of the PEG segments present in their structure, i.e., on their PEG content on a weight/weight basis. At higher PEG contents, partially degraded PLGA segments are brought in solution by attached PEG segments. In all cases, the dissolution rates decrease by increasing the total surface area of the specimens tested.

M. Penco, S. Marcioni, P. Ferruti, S. D'Antone, R. Deghenghi, Degradation behaviour of block copolymers containing poly(lactic-glycolic acid) and poly(ethylene glycol) segments. Biomaterials 17(16) (1996) 1583-1590.
http://www.sciencedirect.com/science/article/B6TWB-3VSG9R5-5/2/ad9da8d0d782c21fcbc1b8ece8123688
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