Tuesday, November 16, 2010

PEG-PCL micelles

The below article discusses the usage of diblock PEG-PCL for formulation of micelles. Find these polymers at www.polyvivo.com, go to the link below or to the original source for full-text for the article. (note the below article did not not necessarily use an Akina product for this research). Abstract follows:

The polymerization of ε−caprolactone (CL) in the presence of HCl · Et2O via activated monomer mechanism was performed to synthesize diblock copolymers composed of methoxy polyethyleneglycol (MPEG) and poly(ε−caprolactone) (PCL). The obtained PCLs had molecular weights close to the theoretical values calculated from the CL to MPEG molar ratios and exibited monomodal GPC curves. We successfully prepared MPEG and PCL diblock copolymers by activated monomer mechanism. The micellar characterization of MPEG-PCL diblock copolymers in an aqueous phase was carried out by using NMR, dynamic light scattering, AFM and fluorescence techniques. The diblock copolymers formed micelles with a critical micelle concentration (CMC) ranging 2.07 x 10-2 - 1.16 x 10-3 mg/mL depended on the block lengths of diblock copolymers. The diameters of micelles, measured by dynamic light scattering, were100-250 nm. Most micelles exhibited a spherical shape in AFM.

M.S. Kim, H. Hyun, Y.H. Cho, K.S. Seo, W.Y. Jang, S.K. Kim, G. Khang, H.B. Lee, Preparation of methoxy poly(ethyleneglycol)-block-poly(caprolactone) via activated monomer mechanism and examination of micellar characterization. Polymer Bulletin 55(3) (2005) 149-156.

FullText:
http://www.springerlink.com/content/j0206u842571rx4m/
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