Method for Prevention or Treatment of Inflammatory Disease
Application number: 11/572,797
Publication number:
Filing date: Jul 25, 2005
Inventors: Gary Steven Firestein, David Louis Boyle, Linda Sue Sorkin
"Methods are provided for prevention or treatment of inflammatory disease in a mammal by administering an inhibitor of mitogen activated (MAP) kinase system to the mammal in a therapeutic amount to the mammal in need thereof. The MAP kinase inhibitor is targeted to the central nervous system of the mammal. Methods are further provided for prevention or treatment of inflammatory disease in a mammal by administering an antagonist of TNF-α to the mammal in a therapeutic amount to the mammal in need thereof. The TNF-α antagonist is targeted to the central nervous system of the mammal."
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