Drug Release from Electric-Field-Responsive Nanoparticles Jun Ge, Evgenios Neofytou, Thomas J. Cahill III, Ramin E. Beygui, and Richard N. Zare ACS NanoArticle ASAPAbstract:
"We describe a new temperature and electric field dual-stimulus responsive nanoparticle system for programmed drug delivery. Nanoparticles of a conducting polymer (polypyrrole) are loaded with therapeutic pharmaceuticals and are subcutaneously localized in vivo with the assistance of a temperature-sensitive hydrogel (PLGA-PEG-PLGA). We have shown that drug release from the conductive nanoparticles is controlled by the application of a weak, external DC electric field. This approach represents a novel interactive drug delivery system that can show an externally tailored release profile with an excellent spatial, temporal, and dosage control."
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