Wednesday, April 11, 2012

PolyVivo for poorly soluble drug delivery

A new whitepaper is available which details the use of PolyVivo AK01 (mPEG-PCL) for generating liposomes/nanoparticles <450nm in size for solubilizing a poorly soluble drug up to almost 500X its native solubility in water.  This was done in laboratory scale with using only a conventional overhead stirrer showing that these can be formed easily using biodegradable block polymers allowing for delivery of a poorly soluble drug without the need for excessive amounts of carrier solution.
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