Friday, February 28, 2014

Dox-PLA-PEG-Fol for cancer treatment

PolySciTech (www.polyscitech.com) provides several PLA-PEG-COOH and PLGA-PEG-COOH precursors/reactive intermediates (e.g. PolyVivo AI37, AI54, AI34 AI56, etc.) for a wide variety of drug delivery applications. Recently similar polymers have been utilized as a precursor towards synthesis of docetaxel conjugated PLA-PEG-Folate polymers which displayed effectiviness against cancer cells in-vitro. Read more at: Hami, Zahra, Mohsen Amini, Mahmoud Ghazi-Khansari, Seyed Mehdi Rezayat, and Kambiz Gilani. "Synthesis and in vitro evaluation of a pH-sensitive PLA-PEG-Folate based polymeric micelle for controlled delivery of docetaxel." Colloids and Surfaces B: Biointerfaces (2014). http://dx.doi.org/10.1016/j.colsurfb.2014.01.015

“Abstract:  pH-responsive docetaxel-conjugated poly (lactic acid) (PLA)–polyethyleneglycol (PEG) micellar formulation was synthesized via acid labile hydrazone linkage. Levulinic acid (LEV) was used as a linker between docetaxel (DTX) and hydrazine. Targeted delivery of DTX was achieved by conjugation of folate to PEG segment. The DTX conjugated polymeric micelles were about 181 nm in diameter and their critical micelle concentration was 5.18 μg/ml. DTX was released from micelles in a pH-dependent manner. The results showed a significant difference in DTX release from polymeric micelles at pH 5.0 and pH 7.4. Cytotoxicity assays using methyl tetrazolium (MTT), neutral red (NR) and lactate dehydrogenase (LDH) demonstrated a decreased cytotoxic activity of the drug containing nanoconjugate compared with free DTX that appears to be contributed to the sustained release of drug from micelles. Based on these results, it is expected that this pH-responsive nanoconjugate is promising as a useful carrier for targeted delivery of anticancer agents.”
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