Tuesday, February 25, 2014

PCL-PEG-PCL for reduced post-surgical adhesion

PolyScitech (www.polyscitech.com) provides triblock PCL-PEG-PCL block copolymers (e.g. polyvivo AK35 etc.). Recently similar polymers have been utilized to generate thermosensitive micelles which act to reduce postoperative adhesion. Read more at: Wu, Qinjie, Ling Li, Ning Wang, Xiang Gao, Bilan Wang, Xinyu Liu, Zhiyong Qian, Yuquan Wei, and Changyang Gong. "Biodegradable and thermosensitive micelles inhibit ischemia-induced postoperative peritoneal adhesion." International journal of nanomedicine 9 (2014): 727. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921091/

“Abstract: Ischemia-induced adhesion is very common after surgery, and leads to severe abdominal adhesions. Unfortunately, many existing barrier agents used for adhesion prevention have only limited success. The objective of this study is to evaluate the efficacy of biodegradable and thermosensitive poly(ε-caprolactone)–poly(ethylene glycol)–poly(ε-caprolactone) (PCL–PEG–PCL) micelles for the prevention of postoperative ischemia-induced adhesion. We found that the synthesized PCL–PEG–PCL copolymer could self-assemble in an aqueous solution to form micelles with a mean size of 40.1±2.7 nm at 10°C, and the self-assembled micelles could instantly turn into a nonflowing gel at body temperature. In vitro cytotoxicity tests suggested that the copolymer showed little toxicity on NIH-3T3 cells even at amounts up to 1,000 μg/mL. In the in vivo test, the postsurgical ischemic-induced peritoneal adhesion model was established and then treated with the biodegradable and thermosensitive micelles. In the control group (n=12), all animals developed adhesions (mean score, 3.58±0.51), whereas three rats in the micelles-treated group (n=12) did not develop any adhesions (mean score, 0.67±0.78; P<0 .001="" 7="" a="" adhesion.="" adhesion="" adhesions.="" after="" agent="" and="" antiadhesion="" as="" barrier="" biodegradable="" both="" caprolactone="" cells="" complications="" confirmed="" could="" day="" demonstrated="" effect="" effects="" emerged="" eosin="" ethylene="" even="" excellent="" experiments.="" formation="" glycol="" had="" hematoxylin="" hitney="" in="" indicated="" injured="" ischemia-induced="" ischemic="" keywords:="" layer="" mann="" masson="" micelle="" micelles.="" micelles="" neo-mesothelial="" no="" of="" on="" pcl="" poly="" postsurgical="" potential="" prevent="" reduce="" results="" serve="" severity="" side="" significant="" span="" staining="" suggested="" surgical="" that="" the="" therapeutic="" thermosensitive="" these="" tissues="" to="" treatment="" trichrome="" u-test="" vivo="" which="">
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