Monday, February 24, 2014

Publication uses Akina products for intranasal treatment of schizophrenia

New publication out using PolySciTech (www.polyscitech.com) products. Recent paper published by Piazza et. al. utilizes a combination of methoxy-PEG-PLGA and Mal-PEG-PLGA as precursors for generating Solanum tuberosum lectin conjugated nanoparticles capable of intranasally delivering haloperidol to the brain as a potential treatment for schizophrenia.  Read more at: Piazza, Justin, Todd Hoare, Luke Molinaro, Kristen Terpstra, Jayant Bhandari, P. Ravi Selvaganapathy, Bhagwati Gupta, and Ram K. Mishra. "Intranasally Administered Lectin Functionalized poly (ethylene glycol)–block-poly (D, L)-lactic-co-glycolic acid (PEG-PLGA) Nanoparticles for the Treatment of Schizophrenia."European Journal of Pharmaceutics and Biopharmaceutics (2014). http://dx.doi.org/10.1016/j.ejpb.2014.02.007

“Abstract: Lectin-functionalized, polyethylene glycol–block-poly-(d,l)-lactic-co-glycolic acid nanoparticles loaded with haloperidol were prepared with narrow size distributions and sizes <135 1.5="" 6="" 96="" a="" administration.="" administration="" amount="" and="" antipsychotic="" at="" be="" binding="" both="" bovine="" brain="" by="" capacities.="" catalepsy.="" compared="" concentrations="" conditions="" conjugation="" d2="" demonstrates="" demonstrating="" displacing="" dopamine="" dose="" drug="" drugs="" effect="" effective="" efficiencies="" efficient="" encapsulation="" endo-lysosomal="" erosion="" exhibited="" fold="" for="" formulation="" formulations="" found="" h="" haloperidol-loaded="" haloperidol="" high="" highly="" in="" increased="" inducing="" intranasal="" leakage="" lectin="" loaded="" loading="" minimal="" n-propylnorapomorphine="" nanoparticle="" nanoparticles="" necessary="" nm.="" non-stl-functionalized="" of="" other="" over="" particles="" potential="" produce="" promise="" receptors.="" reduction="" release="" released="" routes="" schizophrenia.="" solanum="" span="" stl-functionalized="" striatal="" successful="" targeted="" the="" therapeutic="" this="" tissue.="" tissue="" to="" transport="" treatment="" tuberosum="" upon="" vitro="" was="" were="" with="">


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