Wednesday, March 19, 2014

PLGA for bone scaffold use

PolySciTech (www.polyscitech.com) provides a wide variety of PLGA’s and related derivatives. Curious about learning more about PLGA. There is an excellent review article available in full-text version at the below link.  This article describes PLGA with an emphasis on bone tissue enginerring including such techniques as utilizing PLGA-NH2 endcap for anchoring bioactive molecules onto a scaffold. Read more here: Gentile, Piergiorgio, Valeria Chiono, Irene Carmagnola, and Paul V. Hatton. "An Overview of Poly (lactic-co-glycolic) Acid (PLGA)-Based Biomaterials for Bone Tissue Engineering." International journal of molecular sciences 15, no. 3 (2014): 3640-3659. http://www.mdpi.com/1422-0067/15/3/3640/pdf

“Abstract: Poly(lactic-co-glycolic) acid (PLGA) has attracted considerable interest as a base material for biomedical applications due to its: (i) biocompatibility; (ii) tailored biodegradation rate (depending on the molecular weight and copolymer ratio); (iii) approval for clinical use in humans by the U.S. Food and Drug Administration (FDA); (iv) potential to modify surface properties to provide better interaction with biological materials; and (v) suitability for export to countries and cultures where implantation of animal-derived products is unpopular. This paper critically reviews the scientific challenge of manufacturing PLGA-based materials with suitable properties and shapes for specific biomedical applications, with special emphasis on bone tissue engineering. The analysis of the state of the art in the field reveals the presence of current innovative techniques for scaffolds and material manufacturing that are currently opening the way to prepare biomimetic PLGA substrates able to modulate cell interaction for improved substitution, restoration, or enhancement of bone tissue function. Keywords: bone; composite; PLGA; scaffolds; tissue engineering.”
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