PolySciTech (www.polyscitech.com) provides a wide
array of biodegradable polymers including PEG, PLGA’s, polyvalerolactones,
poly(TMC)’s, PCL’s, and a variety of speciality copolymers. A great deal of
these polymers can be utilized as component for, amongst other things, delivery
of bioactive agents. Recently an
excellent review paper has been published which lays out the various strategies
and techniques for applications of these delivery systems towards medicine.
Read more: Nguyen, Minh Khanh, and Eben Alsberg. "Bioactive factor
delivery strategies from engineered polymer hydrogels for therapeutic
medicine." Progress in Polymer Science (2014). http://dx.doi.org/10.1016/j.progpolymsci.2013.12.001
“Abstract: Polymer hydrogels have
been widely explored as therapeutic delivery matrices because of their ability
to present sustained, localized and controlled release of bioactive factors.
Bioactive factor delivery from injectable biopolymer hydrogels provides a versatile
approach to treat a wide variety of diseases, to direct cell function and to
enhance tissue regeneration. The innovative development and modification of
both natural- (e.g., alginate (ALG), chitosan, hyaluronic acid (HA), gelatin,
heparin (HEP), etc.) and synthetic- (e.g., polyesters, polyethyleneimine (PEI),
etc.) based polymers has resulted in a variety of approaches to design drug
delivery hydrogel systems from which loaded therapeutics are released. This
review presents the state-of-the-art in a wide range of hydrogels that are
formed though self-assembly of polymers and peptides, chemical crosslinking,
ionic crosslinking and biomolecule recognition. Hydrogel design for bioactive
factor delivery is the focus of the first section. The second section then
thoroughly discusses release strategies of payloads from hydrogels for
therapeutic medicine, such as physical incorporation, covalent tethering,
affinity interactions, on demand release and/or use of hybrid polymer
scaffolds, with an emphasis on the last 5 years.
Abbreviations: GFs, growth
factors; ALG, alginate; HA, hyaluronic acid; HEP, heparin; PEI,
polyethyleneimine; PHEMA, poly(2-hydroxyethyl methacrylate); PEG, poly(ethylene
glycol); PEO, poly(ethylene oxide); DEX, dextran; PPO, poly(propylene oxide);
PPG, poly(propylene glycol); (PNIPAm), poly(N-isopropylacrylamide);
PEO-PPO-PEO, poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide);
Pluronic®, same as PEO-PPO-PEO; HDI, hexamethylene diisocyanate; PCL,
poly(ɛ-caprolactone); PLA, poly(lactic acid); ROP, ring opening polymerization
Sn(oct)2 stannous octoate; DEGDVE, di-(ethylene glycol) divinylether; p-TSA,
p-toluenesulfonic anhydride; PGA, poly(glycolic acid); PHB,
poly[(R)-3-hydroxybutyrate]; PLGA, poly(d,l-lactide-co-glycolide); MPEG,
monomethoxy poly(ethylene glycol); DLLA, D,l-lactide; GA, glycolide; PVL,
poly(δ-valerolactone); HB, (R)-3-hydroxybutyrate; EG, ethylene glycol; ATRP,
atom transfer radical polymerization; MPC, poly(2-methacryloyloxyethyl
phosphorylcholine); DEDBA, diethyl-meso-2,5-dibromoadipate; Cu(I)Br, copper(I)
bromide; Me4Cyclam, 1,4,8,11-tetramethyl-1,4,8,11-tetraazacyclo-tetradecane;
RAFT, reversible addition-fragmentation chain transfer; PNIPAm-PMMA,
poly(NIPAm-b-methyl methacrylate); macro-CTA, macromer containing chain
transfer agent; AIBN, 2,2′-azobis(2-methylpropionitrile); MCPDB,
S-methoxycarbonylphenylmethyl dithiobenzoate; AlCl3, aluminum chloride; IleOEt,
l-isoleucine ethyl ester; LeuOEt, d,l-leucine ethyl ester; ValOEt, l-valine
ethyl ester; PPF, poly(propylene fumarate); ZnCl2, zinc chloride; PLLA,
poly(l-lactide); PDLA, poly(d-lactide); NaBH3CN, cyanoborohydride; PAA,
poly(amidoamine); TMDP, 4,4-trimethylene dipiperidine; P(DEGMMA-co-MAA),
poly(methoxydi(ethylene glycol) methacrylate-co-methacrylic acid); PAUU,
poly(amino urea urethane); OSM, oligomer sulfamethazine; DMAP,
4-(dimethylamino)pyridine; DCC, N,N′-dicyclohexylcarbodiimide; PAE,
poly(β-aminoester); BDA, 1,4-butandiol diacrylate; PAEU, poly(amino ester
urethane); PANHS, palmitic acid N-hydroxysuccinimide; CD, cyclodextrins; HPMA,
poly(N-(2-hydroxypropyl)methacrylamide); APMA, N-(3-aminopropyl)methacrylamide;
PA, polyalanine; NCA, carboxy anhydrides; PLX, PPG-PEG-PPG bis(2-aminopropyl
ether); AC, acryloyl chloride; Irgacure 651, 2,2-dimethoxy-2-phenylacetophenone;
PEGDA, poly(ethylene glycol) diacrylate; PEGLADA, poly(ethylene glycol)-lactic
acid-diacrylate; PHPMAlac, poly(N-(2-hydroxypropyl)methacrylamide lactate);
Irgacure 2959, 4-(2-hydroxyethoxy)phenyl-(2-hydroxy-2-propyl)ketone; ALG-MA,
methacrylated alginate; EDC, 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide
hydrochloride; NHS, N-hydroxysuccinimide; AEMA, 2-aminoethyl methacrylate; CMC,
carboxymethylcellulose; PEGDM, poly(ethylene glycol) dimethacrylate; NORB,
5-norbornene-2-carboxylic acid; NASI, N-acryloxysuccinimide; DTP,
dithiobis(propanoicdihydrazide); DTT, dithiothreitol; DEX-SH,
thiolated-dextran; DEX-VS, dextran-vinyl sulfone; MMP, matrix
metalloproteinase; NaIO4(NH4)2S2O8, sodium periodate ammonium persulfate;
NaOCl, sodium hypochlorite; NaBH4, sodium borohydride; DTB, dithiobis(butyric
dihydrazide); SPDP, N-succinimidyl 3-(2-pyridyldithio)propionate; DEX-CHO,
aldehyde-modified dextran; AAD, adipic acid dihydrazide; Na2B4O7, sodium
tetraborate; CMC-CHO, oxidized carboxymethylcellulose; CMDX-ADH,
hydrazide-modified carboxymethyldextran; HA-CHO, oxidized hyaluronic acid;
S-chitosan, N-succinyl-chitosan; HRP, horseradish peroxidase; TGase,
transglutaminase; PVA, poly(vinyl alcohol); CDI, N,N′-carbonyldiimidazole; APS,
ammonium persulfate; TEMED, N,N,N′,N′-tetramethylethylene diamine; P(PF-co-EG),
poly(propylene fumarate-co-ethylene glycol); o-NBE, ortho-nitrobenzylether;
BGP, β-glycerophosphate disodium salt; G, α-guluronic acid; CaSO4, calcium
sulfate; CaCl2, calcium chloride; CaCO3, calcium carbonate; semi-IPN,
semi-interpenetrating network; GAR IgG, goat anti-rabbit immunoglobulin G; AAm,
acrylamide; MBA, N,N′-methylene bisacrylamide; AAc, acrylic acid; AFP, anti-AFP
anti-α-fetoprotein antibody; PPxY, proline-rich peptide; DDD, docking and
dimerization domain; cAMP, cyclic adenosine monophosphate; PKA, protein kinase
A; AD, anchoring domain; AKAP, A-kinase anchoring protein; DMT, dexamethasone;
SD, Sprague Dawley; 5-FU, 5-fluorouracyl; Ig, bovine γ-globulin; BSA, bovine
serum albumin; siRNA, short interfering ribonucleic acid; GLP-1, glucagon-like
peptide-1; DOX, doxorubicin; PAC, paclitaxel; AmB, amphotericin B; VEGF,
vascular endothelial growth factor; GAG, glycosaminoglycan; β-NGF, β-nerve
growth factor; PDGF-BB, platelet derived growth factor-BB; GDNF, glial-derived
neurotrophic factor; bFGF, basic fibroblast growth factor; TGF-β1, transforming
growth factor-β1; BMP-2, bone morphogenetic protein-2; SPR, surface plasmon
resonance; SELEX, systematic evolution of ligands by exponential enrichment;
PCR, polymerase chain reaction; ICG, indocyanine green; GOD, glucose oxidase;
Con A, concanavalin A; PBA, phenylboronic acid; PNIPMAAm,
poly(N-isopropylmethacrylamide); CaM, calmodulin; TFP, trifluoperazine; LCST,
lower critical solution temperature; AMF, alternating magnetic field; XG,
xanthan gum; UCNP, upconverting nanoparticle
Keywords: Polymerization;
Polymeric biomaterial; Bioactive molecules; Controlled release; Release
mechanism”
No comments:
Post a Comment