New Product, PolyScitech (
www.polyscitech.com) is proud to provide
allyl lactide monomer. This monomer is useful for the generation of side-chain modified PLA’s such as cationic polylactide created by thiol-ene click reaction. Read more: Chen, Chih‐Kuang, Wing‐Cheung Law, Ravikumar Aalinkeel, Bindukumar Nair, Atcha Kopwitthaya, Supriya D. Mahajan, Jessica L. Reynolds et al. "Well‐Defined Degradable Cationic Polylactide as Nanocarrier for the Delivery of siRNA to Silence Angiogenesis in
Prostate Cancer." Advanced healthcare materials 1, no. 6 (2012): 751-761.
“Abstract: Well-defined tertiary
amine-functionalized cationic polylactides (CPLAs) are synthesized by thiol-ene
click functionalization of an allyl-functionalized polylactide, and utilized
for the delivery of interleukin-8 (IL-8) siRNA via CPLA-IL-8 siRNA nanoplexes.
The CPLAs possess remarkable hydrolytic degradability, and their cytotoxicity
is relatively low. The CPLA-IL-8 siRNA nanoplexes can be readily taken up by
prostate cancer cells, resulting in significant IL-8 gene silencing. It is
found that the degradability and cytotoxicity of CPLAs, as well as the
transfection efficiency of the CPLA-IL-8 siRNA nanoplexes, positively correlate
with the amine mol% of CPLAs. Keywords: cationic polymer;degradable
polymer;prostate cancer;gene delivery;RNAi”
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