Friday, April 18, 2014

New Product: mPEG-b-poly(5-benzyloxytrimethylene carbonate)

PolySciTech (www.polyscitech.com) is proud to present a new product. mPEG-b-poly(5-benzyloxytrimethylene carbonate) copolymer is now available (PolyVivo AK78).  Similar copolymers have previously been used for a wide array of micelle based drug delivery applications and this polymer has been shown to be biodegradable and non-cytotoxic. Read more: Zeng, Faquan, Jubo Liu, and Christine Allen. "Synthesis and Characterization of Biodegradable Poly (ethylene glycol)-b lock-poly (5-benzyloxy-trimethylene carbonate) Copolymers for Drug Delivery." Biomacromolecules 5, no. 5 (2004): 1810-1817. http://pubs.acs.org/doi/abs/10.1021/bm049836a


“Abstract: Amphiphilic diblock copolymers with various block compositions were synthesized with monomethoxy-terminated poly(ethylene glycol) (MePEG) as the hydrophilic block and poly(5-benzyloxy-trimethylene carbonate) (PBTMC) as the hydrophobic block. When the copolymerization was conducted using MePEG as a macroinitiator and stannous 2-ethylhexanoate (Sn(Oct)2) as a catalyst, the molecular weight of the second block was uncontrollable, and the method only afforded a mixture of homopolymer and copolymer with a broad molecular weight distribution. By contrast, the use of the triethylaluminum-MePEG initiator yielded block copolymers with controllable molecular weight and a more narrow molecular weight distribution than the copolymers obtained using Sn(Oct)2. GPC and 1H NMR studies confirmed that the macroinitiator was consumed and the copolymer composition was as predicted. Two of the newly synthesized MePEG-b-PBTMC copolymers were evaluated in terms of properties primarily relating to their use in micellar drug delivery. MePEG-b-PBTMC micelles with a narrow monomodal size distribution were prepared using a high-pressure extrusion technique. The MePEG-b-PBTMC copolymers were also confirmed to be biodegradable and noncytotoxic.”

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