PolySciTech (
www.polyscitech.com) provides a wide
array of PEG-PLGA and related activatable polymers. Recently these types of poylmers have been
utilized to generate a system for delivering drugs to glioma cells via Pep-1/IL-13Ra2
binding. Read more: Wang, Baoyan, Lingyan Lv, Zhongyuan Wang, Yue Zhao, Lin Wu,
Xiaoling Fang, Qunwei Xu, and Hongliang Xin. "Nanoparticles functionalized
with Pep-1 as potential glioma targeting delivery system via interleukin 13
receptor α2-mediated endocytosis." Biomaterials 35, no. 22 (2014):
5897-5907. http://www.sciencedirect.com/science/article/pii/S0142961214003287
“Abstract: The treatment for glioma is one of
the most challenging problems and therapeutic effect of glioma is often limited
due to poor penetration into the tumor tissue. Interleukin 13 receptor α2
(IL-13Rα2) is over-expressed on tumor including established glioma cell lines
and primary glioblastoma cell cultures. However, it will not cause activation
of its signaling pathways. So it could be served as a promising targeted moiety
for anti-glioma drug delivery. Pep-1, one specific ligand of IL-13Rα2, was
identified to exhibit excellent capacity of crossing the blood tumor barrier
(BTB) and homing to giloma. In this study, based on the IL-13Rα2-mediated
endocytosis, Pep-1 was exploited as a potential ligand for effective
glioma-targeting delivery. Pep-1 was functionalized to the surface of PEG-PLGA
nanoparticles (Pep-NP) to evaluate its glioma homing, by taking advantage of
the excessive expression of the IL-13Rα2 on the surface of glioma cells.
Compared with non-targeting nanoparticles, Pep-NP exhibited a significantly
enhanced cellular association in rat C6 glioma cells and improved penetration
in 3D avascular C6 glioma spheroids. Following intravenous administration,
Pep-NP could facilitate the distribution of the coumarin-6 in vivo glioma
region, 2.21 times higher than that of NP for quantitative analysis. In
conclusion, the Pep-NP could precisely target to the brain glioma, which was a
potential targeting drug delivery system for glioma treatment. Keywords: Glioma;
Blood tumor barrier (BTB); Interleukin 13 receptor α2; Pep-1 peptide; Targeting
nanoparticles”
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