PolySciTech (www.polyscitech.com) provides a wide
array of amine endcapped PLGA’s, PLA’s, and PCL’s. The effect of amine endcapping is that these
polymers can react easily with a variety of chemistries notably
carbodiimide/NHS type reactions. Recently this type of polymer and reaction was
utilized to attach heparin to PLA surface to improve hemocompatibility. Read
more: Sharkawi, Tahmer, Vincent Darcos, and Michel Vert. “Poly (DL‐lactic
acid) film surface modification with heparin for improving hemocompatibility of blood contacting
bioresorbable devices." Journal of Biomedical Materials Research Part A
98, no. 1 (2011): 80-87. http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.33099/full
“Abstract: This work describes a simple method
to immobilize heparin by covalent bonding to the surface of poly(lactic acid)
film with the aim of showing improved hemocompatibility. Carboxyl groups
present in heparin molecules were activated by reaction with
N-hydroxy-succinimide and allowed to react with free amino groups created at
the surface of poly(dl-lactic acid) films by controlled aminolysis. Contact
angle measurements and XPS analysis confirmed the binding. Quantification was
determined by radioactivity using heparin labeled with tritium. The surface
exhibited anti factor Xa activity, thus confirming the presence of bounded
heparin that kept some biological activity. Finally platelets adhesion showed
less platelet adhesion on heparin modified films as well as preserved
morphology. Keywords: poly(lactic acid);surface modification;heparin
immobilization;hemocompatibility;platelet adhesion;bioresorbable;cardiovascular
medical device”
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