PolySciTech (
www.polyscitech.com) provides a wide
array of PEG-PLGA block copolymers. Recently these types of polymers have been
applied to developing cancer diagnostic delivery systems by loading
perfluorooctyl bromide (Ultrasound/MRI contrast agent). Read more: Diou, O., E. Fattal, T. Payen, S.
L. Bridal, J. Valette, and N. Tsapis. "Nanocapsules of perfluorooctyl
bromide for theranostics: from formulation to in vivo targeting." In SPIE
BiOS, pp. 895514-895514. International Society for Optics and Photonics, 2014. http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=1852594
“Abstract: The need to detect cancer at its
early stages, as well as, to deliver chemotherapy to targeted site motivates
many researchers to build theranostic platforms which combine diagnostic and
therapy. Among imaging modalities, ultrasonography and Magnetic Resonance
Imaging (MRI) are widely available, non invasive and complement each other.
Both techniques often require the use of contrast agents. We have developed
nanocapsules of perfluorooctyl bromide as dual contrast agent for both imaging
modalities. The soft, amorphous polymer shell provides echogenicity, while the
high-density perfluorinated liquid core allows detection by 19F MRI. We have
used a shell of poly(lactide-co-glycolide) (PLGA) since this polymer is
biodegradable, biocompatible and can be loaded with drugs. These capsules were
shown to be efficient in vitro as contrast agents for both 19F MRI and
ultrasonography. In addition, for in vivo applications a poly(ethyleneglycol)
(PEG) coating promotes stability and prolonged circulation. Being stealth,
nanocapsule can accumulate passively into implanted tumors by the EPR effect.
We will present nanocapsule formulation and characterization, and will show
promising in vivo results obtained for both ultrasonography and 19F MRI Topics:
Cancer ; Coating ; Diagnostics ; Magnetic resonance imaging ; Polymers ;
Ultrasonography”
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