PolySciTech (
www.polyscitech.com) provides a wide
variety of PLGA polymers as well as chitosan derivatives (kitopure). Recently
these types of polymers were used to develop an inhaled microparticle system
for the delivery of 2-methoxyestradiol to lung tissue with minimal irritation.
Read more: Guo, XinHong, XinXin Zhang, Ling Ye, Ying Zhang, Rui Ding, YongWei
Hao, YaLin Zhao, ZhenZhong Zhang, and Yun Zhang. "Inhalable microspheres
embedding chitosan-coated PLGA nanoparticles for 2-methoxyestradiol."
Journal of drug targeting 0 (2014): 1-7. http://informahealthcare.com/doi/abs/10.3109/1061186X.2013.878944
“Abstract: Developing a highly effective and
lung-targeted local drug delivery carrier with low irritancy may be critical
for improving treatment of lung cancer. Using soluble excipients as
microspheres (MS) matrix, respirable MS embedding chitosan-coated
poly(d,l-lactide-co-glycolide) nanoparticles (CNP-MS) for 2-methoxyestradiol
(2-ME) were designed, which could avoid macrophage phagocytosis to achieve the
targeted delivery of these drugs. 2-ME CNP-MS were prepared by spray-drying and
characterized by morphology, redispersability, fine particle fraction (FPF) and
drug release. Cytotoxicity, and lung deposition and histological examination
were investigated. Results showed that 2-ME CNP-MS were spherical with a rough
surfaces, exhibiting good redispersability, a high respirable fraction and
sustained release characteristics. CNP-MS markedly enhanced the cytotoxicity of
2-ME by approximately 8.8-fold and 3.65-fold on SPC-A1 cells compared to
solution and NP, respectively. After pulmonary administration, 2-ME CNP were
distributed in rat lungs and for 10 mg of 2-ME CNP-MS, haematoxylin and eosin
staining showed no obvious difference compared to the untreated control group.
Therefore, CNP-MS revealed suitable features for local lung delivery and
significantly enhanced cytotoxicity of 2-ME without obvious inflammation in
lungs of rats, suggesting that 2-ME CNP-MS have great potential as an
inhalation agent for targeted, highly effective and safe treatment of lung
cancer. Keywords Cytotoxicity, fine particle fraction, in vivo, inflammation,
local lung delivery, spray-drying”
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