PolySciTech (
www.polyscitech.com) provides a variety
of poly(ethylene glycol)-b-poly(trimethylene carbonate) copolymers. Recently
similar polymers have been utilized to generate a cancer targeting system based
on glucosamine. Read more: http://onlinelibrary.wiley.com/doi/10.1002/jps.23928/full
“Abstract: The poor selectivity of
chemotherapeutics for cancer treatment may lead to dose-limiting side effects
that compromise clinical outcomes. To solve the problem, surface-functionalized
polymer nanoparticles are regarded as promising tumor-targeting delivery
system. On the basis of glucose transporter (GLUT) overexpression on cancer
cells, d-glucosamine-conjugated and paclitaxel-loaded poly(ethylene
glycol)-co-poly(trimethylene carbonate) copolymer nanoparticles (DGlu-NP/PTX)
were developed as potential tumor-targeting drug delivery system in this study.
Because of the high affinity between d-glucosamine and GLUT, DGlu-NP/PTX could
target to tumor tissue through GLUT-mediated endocytosis to improve the selectivity
of PTX. DGlu-NP/PTX was prepared by emulsion/solvent evaporation technique and
characterized in terms of morphology, size, and zeta potential. In vitro
evaluation of two-dimensional cells and three-dimensional tumor spheroids
revealed that DGlu-NP/PTX was more potent than those of plain nanoparticles
(NP/PTX) and Taxol. In vivo multispectral fluorescent imaging indicated that
DGlu-NP had higher specificity and efficiency on subcutaneous xenografts tumor
of mouse. Furthermore, DGlu-NP/PTX showed the greatest tumor growth inhibitory
effect on in vivo subcutaneous xenografts model with no evident toxicity.
Therefore, these results demonstrated that DGlu-NP/PTX could be used as
potential vehicle for cancer treatment
Keywords: nanoparticles;paclitaxel;d-Glucosamine;GLUT;tumor-targeting
delivery system;biomaterials;drug delivery system;biodegradable;polymers;cancer
chemotherapy”
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